RNA Is a Double-Edged Sword in ALS Pathogenesis

by Benjamin L. Zaepfel, Benjamin L. Zaepfel, Jeffrey D. Rothstein, Jeffrey D. Rothstein
Published 2021-07-01

Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction.

by Sean J Miller, Jeffrey D Rothstein
Published 2016-01-01

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

by Alyssa N. Coyne, Jeffrey D. Rothstein
Published 2021-07-01

Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD

by Alyssa N. Coyne, Jeffrey D. Rothstein
Published 2021-03-01

Glutamate transporters: animal models to neurologic disease

by Nicholas J Maragakis, Jeffrey D Rothstein
Published 2004-04-01

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

by Lindsey R Hayes, Lauren Duan, Kelly Bowen, Petr Kalab, Jeffrey D Rothstein
Published 2020-03-01

GLT-1 promoter activity in astrocytes and neurons of mouse hippocampus and somatic sensory cortex

by Luisa De Vivo, Marcello Melone, Jeffrey D Rothstein, Fiorenzo Conti, Fiorenzo Conti
Published 2010-01-01

Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection

by Raquelli Ganel, Tony Ho, Nicholas J. Maragakis, Mandy Jackson, Joseph P. Steiner, Jeffrey D. Rothstein
Published 2006-03-01

Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

by Mitsunori Watanabe, Margaret Dykes-Hoberg, Valeria Cizewski Culotta, Donald L. Price, Philip C. Wong, Jeffrey D. Rothstein
Published 2001-12-01

Preclinical Testing of Neuroprotective Neurotrophic Factors in a Model of Chronic Motor Neuron Degeneration

by Andrea M. Corse, Masako M. Bilak, Stephan R. Bilak, Mohamed Lehar, Jeffrey D. Rothstein, Ralph W. Kuncl
Published 1999-10-01

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS

by Christine Haenggeli, Jean-Pierre Julien, R. Lee Mosley, Natalie Perez, Alok Dhar, Howard E. Gendelman, Jeffrey D. Rothstein
Published 2007-04-01

A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.

by Ying Li, Umamahesw Balasubramanian, Devon Cohen, Ping-Wu Zhang, Elizabeth Mosmiller, Rita Sattler, Nicholas J Maragakis, Jeffrey D Rothstein
Published 2015-01-01

The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

by Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng, Peter C. Searson
Published 2019-07-01

Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex

by Antoine M Valera, Francesca Binda, Sophie A Pawlowski, Jean-Luc Dupont, Jean-François Casella, Jeffrey D Rothstein, Bernard Poulain, Philippe Isope
Published 2016-03-01

Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS

by Jerònia Lladó, Christine Haenggeli, Andrea Pardo, Victor Wong, Leah Benson, Carol Coccia, Jeffrey D. Rothstein, Jeremy M. Shefner, Nicholas J. Maragakis
Published 2006-01-01

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

by Benjamin L. Zaepfel, Zhe Zhang, Kirstin Maulding, Alyssa N. Coyne, Weiwei Cheng, Lindsey R. Hayes, Thomas E. Lloyd, Shuying Sun, Jeffrey D. Rothstein
Published 2021-03-01

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

by Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein
Published 2021-01-01

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

by Yueming Chang, Qiongman Kong, Xiu Shan, Guilian Tian, Hristelina Ilieva, Don W Cleveland, Jeffrey D Rothstein, David R Borchelt, Philip C Wong, Chien-Liang Glenn Lin
Published 2008-08-01

Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

by Shaopeng Wang, Malgorzata J. Latallo, Zhe Zhang, Bo Huang, Dmitriy G. Bobrovnikov, Daoyuan Dong, Nathan M. Livingston, Wilson Tjoeng, Lindsey R. Hayes, Jeffrey D. Rothstein, Lyle W. Ostrow, Bin Wu, Shuying Sun
Published 2021-08-01

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

by Laurent Roybon, Nuno J. Lamas, Alejandro Garcia-Diaz, Eun Ju Yang, Rita Sattler, Vernice Jackson-Lewis, Yoon A. Kim, C. Alan Kachel, Jeffrey D. Rothstein, Serge Przedborski, Hynek Wichterle, Christopher E. Henderson
Published 2013-09-01