Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major cellular component of TB lung granulomas and are known to play an important role in containment of Mycobacterium tuberculosis (Mtb) infection. We used cynomolgus macaques, a non-human primate model that recapitulat...

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Bibliographic Details
Main Authors: Hannah Priyadarshini Gideon, JiaYao Phuah, Amy J Myers, Bryan D Bryson, Mark A Rodgers, M Teresa Coleman, Pauline Maiello, Tara Rutledge, Simeone Marino, Sarah M Fortune, Denise E Kirschner, Philana Ling Lin, JoAnne L Flynn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004603

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https://doi.org/10.1371/journal.ppat.1004603

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