The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy

by Chung-Pu Wu, Suresh V. Ambudkar
Published 2014-04-01

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).

by Andaleeb Sajid, Sabrina Lusvarghi, Eduardo E Chufan, Suresh V Ambudkar
Published 2018-01-01

South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy

by N. Rajendra Prasad, Ganesan Muthusamy, Mohana Shanmugam, Suresh V. Ambudkar
Published 2016-03-01

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models [version 1; peer review: 2 approved]

by Sabrina Lusvarghi, Robert W. Robey, Michael M. Gottesman, Suresh V. Ambudkar
Published 2020-01-01

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.

by Megan R Ansbro, Suneet Shukla, Suresh V Ambudkar, Stuart H Yuspa, Luowei Li
Published 2013-01-01

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein

by Maria João Moreno, Patrícia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar
Published 2021-03-01

The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions.

by Jasjeet Bhullar, Karthika Natarajan, Suneet Shukla, Trevor J Mathias, Mariola Sadowska, Suresh V Ambudkar, Maria R Baer
Published 2013-01-01

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).

by Eduardo E Chufan, Khyati Kapoor, Hong-May Sim, Satyakam Singh, Tanaji T Talele, Stewart R Durell, Suresh V Ambudkar
Published 2013-01-01

The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

by Chung-Pu Wu, Sabrina Lusvarghi, Jyun-Cheng Wang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Suresh V. Ambudkar
Published 2019-12-01

Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element

by Hadiar Rahman, Andrew Rudrow, Joshua Carneglia, Sister Stephen Patrick Joly, Dante Nicotera, Michael Naldrett, John Choy, Suresh V. Ambudkar, John Golin
Published 2020-01-01

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

by Yuqi Yang, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang
Published 2021-02-01

BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance

by Yunali V. Ashar, Jingchun Zhou, Pranav Gupta, Qiu-Xu Teng, Zi-Ning Lei, Sandra E. Reznik, Sabrina Lusvarghi, John Wurpel, Suresh V. Ambudkar, Zhe-Sheng Chen
Published 2020-09-01

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat

by Chung-Pu Wu, Cheng-Yu Hung, Sabrina Lusvarghi, Yen-Fu Chang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh. V. Ambudkar
Published 2021-03-01

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance

by Zhuo-Xun Wu, Yuqi Yang, Qiu-Xu Teng, Jing-Quan Wang, Zi-Ning Lei, Jing-Qiu Wang, Sabrina Lusvarghi, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-01-01

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

by Yuqi Yang, Ning Ji, Ning Ji, Qiu-Xu Teng, Chao-Yun Cai, Jing-Quan Wang, Zhuo-Xun Wu, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen
Published 2020-05-01

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

by Qingbin Cui, Qingbin Cui, Chao-Yun Cai, Hai-Ling Gao, Hai-Ling Gao, Liang Ren, Ning Ji, Ning Ji, Pranav Gupta, Yuqi Yang, Suneet Shukla, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2019-04-01

Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents

by Chung-Pu Wu, Chung-Pu Wu, Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Ya-Chen Chi, Sung-Han Hsiao, Yang-Hui Huang, Yang-Hui Huang, Tai-Ho Hung, Tai-Ho Hung, Suresh V. Ambudkar
Published 2021-07-01

The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

by Pei-Rong Ding, Amit K Tiwari, Amit K Tiwari, Shinobu Ohnuma, Jeferson W K K Lee, Xin An, Chun-Ling Dai, Qi-Si Lu, Satyakam Singh, Dong-Hua Yang, Tanaji T Talele, Suresh V Ambudkar, Zhe-Sheng Chen
Published 2011-04-01

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

by Kristen M Pluchino, Dominic Esposito, Janna K Moen, Matthew D Hall, James P Madigan, Suneet Shukla, Lauren V Procter, Vanessa E Wall, Thomas D Schneider, Ian Pringle, Suresh V Ambudkar, Deborah R Gill, Steven C Hyde, Michael M Gottesman
Published 2015-01-01

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

by Diogo Henrique Kita, Nathalie Guragossian, Ingrid Fatima Zattoni, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego, Sabrina Lusvarghi, Thomas Moulenat, Billel Belhani, Geraldo Picheth, Sofiane Bouacida, Zouhair Bouaziz, Christelle Marminon, Malika Berredjem, Joachim Jose, Marcos Brown Gonçalves, Suresh V. Ambudkar, Glaucio Valdameri, Marc Le Borgne
Published 2021-01-01