Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells

by Qingbin Cui, Chao-Yun Cai, Jing-Quan Wang, Shuang Zhang, Pranav Gupta, Ning Ji, Yuqi Yang, Xingduo Dong, Dong-Hua Yang, Zhe-Sheng Chen
Published 2019-08-01

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

by Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen
Published 2020-07-01

Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells

by Jingqiu Wang, Dong-Hua Yang, Yuqi Yang, Jing-Quan Wang, Chao-Yun Cai, Zi-Ning Lei, Qiu-Xu Teng, Zhuo-Xun Wu, Linguo Zhao, Zhe-Sheng Chen
Published 2020-02-01

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

by Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Zi-Ning Lei, Jing-Quan Wang, Pranav Gupta, Qiu-Xu Teng, Zhe-Sheng Chen, Dexin Kong, Dong-Hua Yang
Published 2018-10-01

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

by Yuqi Yang, Ning Ji, Ning Ji, Qiu-Xu Teng, Chao-Yun Cai, Jing-Quan Wang, Zhuo-Xun Wu, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen
Published 2020-05-01

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

by Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong
Published 2019-06-01

VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study

by Silpa Narayanan, Ying-Fang Fan, Nehaben A. Gujarati, Qiu-Xu Teng, Jing-Quan Wang, Chao-Yun Cai, Yuqi Yang, Anirudh J. Chintalapati, Yixiong Lei, Vijaya L. Korlipara, Zhe-Sheng Chen
Published 2021-09-01

Y6, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance

by Rui-Qiang Zhao, Rui-Qiang Zhao, Rui-Qiang Zhao, Yan Wen, Yan Wen, Pranav Gupta, Zi-Ning Lei, Chao-Yun Cai, Gang Liang, Dong-Hua Yang, Zhe-Sheng Chen, Yu-An Xie
Published 2019-01-01

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

by Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Chao-Yun Cai, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Leli Zeng, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen
Published 2018-10-01

Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

by Jingqiu Wang, Jingqiu Wang, Jing-Quan Wang, Chao-Yun Cai, Qingbin Cui, Qingbin Cui, Yuqi Yang, Zhuo-Xun Wu, Xingduo Dong, Leli Zeng, Leli Zeng, Linguo Zhao, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-02-01

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

by Qingbin Cui, Qingbin Cui, Chao-Yun Cai, Hai-Ling Gao, Hai-Ling Gao, Liang Ren, Ning Ji, Ning Ji, Pranav Gupta, Yuqi Yang, Suneet Shukla, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2019-04-01

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

by Zi-Ning Lei, Qiu-Xu Teng, Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Kimberly W. Lu, Kimberly W. Lu, Dong-Hua Yang, John N. D. Wurpel, Zhe-Sheng Chen
Published 2020-12-01