Regulators of Homologous Recombination Repair as Novel Targets for Cancer Treatment

by Małgorzata ekrajewska, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Marcel A.T.M. Van Vugt
Published 2015-03-01

Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage.

by Renske Altena, Rudolf S N Fehrmann, Hink Boer, Elisabeth G E de Vries, Coby Meijer, Jourik A Gietema
Published 2015-01-01

Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer

by Hagma H. Workel, Nienke van Rooij, Annechien Plat, Diana C.J. Spierings, Rudolf S. N. Fehrmann, Hans W. Nijman, Marco de Bruyn
Published 2020-05-01

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

by Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Published 2019-01-01

Transcriptional effects of copy number alterations in a large set of human cancers

by Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published 2020-02-01

Improving gene function predictions using independent transcriptional components

by Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Published 2021-03-01

Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy

by Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast
Published 2021-08-01

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach.

by Mathilde R W de Jong, Lydia Visser, Gerwin Huls, Arjan Diepstra, Marcel van Vugt, Emanuele Ammatuna, Rozemarijn S van Rijn, Edo Vellenga, Anke van den Berg, Rudolf S N Fehrmann, Tom van Meerten
Published 2018-01-01

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.

by Vinod Kumar, Harm-Jan Westra, Juha Karjalainen, Daria V Zhernakova, Tõnu Esko, Barbara Hrdlickova, Rodrigo Almeida, Alexandra Zhernakova, Eva Reinmaa, Urmo Võsa, Marten H Hofker, Rudolf S N Fehrmann, Jingyuan Fu, Sebo Withoff, Andres Metspalu, Lude Franke, Cisca Wijmenga
Published 2013-01-01

Survival-related profile, pathways, and transcription factors in ovarian cancer.

by Anne P G Crijns, Rudolf S N Fehrmann, Steven de Jong, Frans Gerbens, Gert Jan Meersma, Harry G Klip, Harry Hollema, Robert M W Hofstra, Gerard J te Meerman, Elisabeth G E de Vries, Ate G J van der Zee
Published 2009-02-01

A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

by Thijs T. Wind, Mathilde Jalving, Jacco J. de Haan, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Dirk-Jan Reijngoud, Rozemarijn S. van Rijn, John B. A. G. Haanen, Christian U. Blank, Geke A. P. Hospers, Rudolf S. N. Fehrmann
Published 2019-03-01

Evidence based selection of housekeeping genes.

by Hendrik J M de Jonge, Rudolf S N Fehrmann, Eveline S J M de Bont, Robert M W Hofstra, Frans Gerbens, Willem A Kamps, Elisabeth G E de Vries, Ate G J van der Zee, Gerard J te Meerman, Arja ter Elst
Published 2007-09-01

Comparison of Carboplatin With 5-Fluorouracil vs. Cisplatin as Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

by Saskia H. Hanemaaijer, Iris C. Kok, Rudolf S. N. Fehrmann, Bert van der Vegt, Jourik A. Gietema, Boudewijn E. C. Plaat, Marcel A. T. M. van Vugt, Marije R. Vergeer, C. René Leemans, Johannes A. Langendijk, Jens Voortman, Jan Buter, Sjoukje F. Oosting
Published 2020-06-01

A new perspective on transcriptional system regulation (TSR): towards TSR profiling.

by Rudolf S N Fehrmann, Hendrik J M de Jonge, Arja Ter Elst, André de Vries, Anne G P Crijns, Alida C Weidenaar, Frans Gerbens, Steven de Jong, Ate G J van der Zee, Elisabeth G E de Vries, Willem A Kamps, Robert M W Hofstra, Gerard J Te Meerman, Eveline S J M de Bont
Published 2008-02-01

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.

by Jingyuan Fu, Marcel G M Wolfs, Patrick Deelen, Harm-Jan Westra, Rudolf S N Fehrmann, Gerard J Te Meerman, Wim A Buurman, Sander S M Rensen, Harry J M Groen, Rinse K Weersma, Leonard H van den Berg, Jan Veldink, Roel A Ophoff, Harold Snieder, David van Heel, Ritsert C Jansen, Marten H Hofker, Cisca Wijmenga, Lude Franke
Published 2012-01-01

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

by Rudolf S N Fehrmann, Ritsert C Jansen, Jan H Veldink, Harm-Jan Westra, Danny Arends, Marc Jan Bonder, Jingyuan Fu, Patrick Deelen, Harry J M Groen, Asia Smolonska, Rinse K Weersma, Robert M W Hofstra, Wim A Buurman, Sander Rensen, Marcel G M Wolfs, Mathieu Platteel, Alexandra Zhernakova, Clara C Elbers, Eleanora M Festen, Gosia Trynka, Marten H Hofker, Christiaan G J Saris, Roel A Ophoff, Leonard H van den Berg, David A van Heel, Cisca Wijmenga, Gerard J Te Meerman, Lude Franke
Published 2011-08-01

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

by Alexandra Zhernakova, Eli A Stahl, Gosia Trynka, Soumya Raychaudhuri, Eleanora A Festen, Lude Franke, Harm-Jan Westra, Rudolf S N Fehrmann, Fina A S Kurreeman, Brian Thomson, Namrata Gupta, Jihane Romanos, Ross McManus, Anthony W Ryan, Graham Turner, Elisabeth Brouwer, Marcel D Posthumus, Elaine F Remmers, Francesca Tucci, Rene Toes, Elvira Grandone, Maria Cristina Mazzilli, Anna Rybak, Bozena Cukrowska, Marieke J H Coenen, Timothy R D J Radstake, Piet L C M van Riel, Yonghong Li, Paul I W de Bakker, Peter K Gregersen, Jane Worthington, Katherine A Siminovitch, Lars Klareskog, Tom W J Huizinga, Cisca Wijmenga, Robert M Plenge
Published 2011-02-01

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases:...

by Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul, Hans J. van der Vliet, Marinus J. Wiezer, Djamila Boerma, Emma C. E. Wassenaar, Maartje Los, Cornelis B. Hunting, Arend G. J. Aalbers, Niels F. M. Kok, Koert F. D. Kuhlmann, Henk Boot, Myriam Chalabi, Schelto Kruijff, Lukas B. Been, Robert J. van Ginkel, Derk Jan A. de Groot, Rudolf S. N. Fehrmann, Johannes H. W. de Wilt, Andreas J. A. Bremers, Philip R. de Reuver, Sandra A. Radema, Karin H. Herbschleb, Wilhelmina M. U. van Grevenstein, Arjen J. Witkamp, Miriam Koopman, Nadia Haj Mohammad, Eino B. van Duyn, Walter J. B. Mastboom, Leonie J. M. Mekenkamp, Joost Nederend, Max J. Lahaye, Petur Snaebjornsson, Cornelis Verhoef, Hanneke W. M. van Laarhoven, Aeilko H. Zwinderman, Jeanette M. Bouma, Onno Kranenburg, Iris van ‘t Erve, Remond J. A. Fijneman, Marcel G. W. Dijkgraaf, Patrick H. J. Hemmer, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. J. T. de Hingh, Dutch Peritoneal Oncology Group (DPOG), Dutch Colorectal Cancer Group (DCCG)
Published 2019-04-01