Pharmacomicrobiomics: a novel route towards personalized medicine?

by Marwah Doestzada, Arnau Vich Vila, Alexandra Zhernakova, Debby P. Y. Koonen, Rinse K. Weersma, Daan J. Touw, Folkert Kuipers, Cisca Wijmenga, Jingyuan Fu
Published 2018-04-01

Genetic effects on the commensal microbiota in inflammatory bowel disease patients.

by Hugues Aschard, Vincent Laville, Eric Tchetgen Tchetgen, Dan Knights, Floris Imhann, Philippe Seksik, Noah Zaitlen, Mark S Silverberg, Jacques Cosnes, Rinse K Weersma, Ramnik Xavier, Laurent Beaugerie, David Skurnik, Harry Sokol
Published 2019-03-01

Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

by Karin Fransen, Mitja Mitrovic, Cleo C van Diemen, B K Thelma, Ajit Sood, Andre Franke, Stefan Schreiber, Vandana Midha, Garima Juyal, Uros Potocnik, Jingyuan Fu, Ilja Nolte, Rinse K Weersma
Published 2012-01-01

SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.

by Valerie Collij, Floris Imhann, Arnau Vich Vila, Jingyuan Fu, Gerard Dijkstra, Eleonora A M Festen, Michiel D Voskuil, Mark J Daly, Ramnik J Xavier, Cisca Wijmenga, Alexandra Zhernakova, Rinse K Weersma
Published 2019-01-01

Effects of magnesium citrate, magnesium oxide and magnesium sulfate supplementation on arterial stiffness in healthy overweight individuals: a study protocol for a randomized contr...

by Joëlle C. Schutten, Peter J. Joris, Ronald P. Mensink, Richard M. Danel, Frans Goorman, M. Rebecca Heiner-Fokkema, Rinse K. Weersma, Charlotte A. Keyzer, Martin H. de Borst, Stephan J. L. Bakker
Published 2019-05-01

Characteristics and Dysbiosis of the Gut Microbiome in Renal Transplant Recipients

by J. Casper Swarte, Rianne M. Douwes, Shixian Hu, Arnau Vich Vila, Michele F. Eisenga, Marco van Londen, António W. Gomes-Neto, Rinse K. Weersma, Hermie J.M. Harmsen, Stephan J.L. Bakker
Published 2020-02-01

Exhaled Hydrogen as a Marker of Intestinal Fermentation Is Associated with Diarrhea in Kidney Transplant Recipients

by Fernanda Guedes Rodrigues, J. Casper Swarte, Rianne M. Douwes, Tim J. Knobbe, Camilo G. Sotomayor, Hans Blokzijl, Rinse K. Weersma, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst, TransplantLines Investigators
Published 2021-06-01

Treatment of severe acute ulcerative colitis in SARS-CoV-2 infected patients: report of three cases and discussion of treatment options

by Arno R. Bourgonje, Reinier C. A. van Linschoten, Rachel L. West, Maarten A. van Dijk, Coretta C. van Leer-Buter, Gursah Kats-Ugurlu, Marieke J. Pierik, Eleonora A. M. Festen, Rinse K. Weersma, Gerard Dijkstra
Published 2021-04-01

Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

by Arnau Vich Vila, Valerie Collij, Serena Sanna, Trishla Sinha, Floris Imhann, Arno R. Bourgonje, Zlatan Mujagic, Daisy M. A. E. Jonkers, Ad A. M. Masclee, Jingyuan Fu, Alexander Kurilshikov, Cisca Wijmenga, Alexandra Zhernakova, Rinse K. Weersma
Published 2020-01-01

Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

by Shixian Hu, Werna T. Uniken Venema, Harm-Jan Westra, Arnau Vich Vila, Ruggero Barbieri, Michiel D. Voskuil, Tjasso Blokzijl, Bernadien H. Jansen, Yanni Li, Mark J. Daly, Ramnik J. Xavier, Gerard Dijkstra, Eleonora A. Festen, Rinse K. Weersma
Published 2021-02-01

Recipient's genetic R702W NOD2 variant is associated with an increased risk of bacterial infections after orthotopic liver transplantation.

by Marcel Janse, Bert-Jan F de Rooij, Bart van Hoek, Arie P van den Berg, Robert J Porte, Hans Blokzijl, Minneke J Coenraad, Bouke G Hepkema, Alexander F Schaapherder, Jan Ringers, Rinse K Weersma, Hein W Verspaget
Published 2013-01-01

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.

by Hilbert S de Vries, Theo S Plantinga, J Han van Krieken, Rinke Stienstra, Ad A van Bodegraven, Eleonora A M Festen, Rinse K Weersma, J Bart A Crusius, Ronald K Linskens, Leo A B Joosten, Mihai G Netea, Dirk J de Jong
Published 2009-01-01

A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.

by Eleonora A M Festen, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C Dubois, Caroline Lagacé, Pieter C F Stokkers, Daan W Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A van Heel, Rinse K Weersma, Mark J Daly, Cisca Wijmenga, John D Rioux
Published 2011-01-01

Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

by Lianmin Chen, Valerie Collij, Martin Jaeger, Inge C. L. van den Munckhof, Arnau Vich Vila, Alexander Kurilshikov, Ranko Gacesa, Trishla Sinha, Marije Oosting, Leo A. B. Joosten, Joost H. W. Rutten, Niels P. Riksen, Ramnik J. Xavier, Folkert Kuipers, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Rinse K. Weersma, Jingyuan Fu
Published 2020-08-01

A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease

by Arno R. Bourgonje, Julius Z. H. von Martels, Ruben Y. Gabriëls, Tjasso Blokzijl, Manon Buist-Homan, Janette Heegsma, Bernadien H. Jansen, Hendrik M. van Dullemen, Eleonora A. M. Festen, Rinze W. F. ter Steege, Marijn C. Visschedijk, Rinse K. Weersma, Paul de Vos, Klaas Nico Faber, Klaas Nico Faber, Gerard Dijkstra
Published 2019-11-01

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.

by Jingyuan Fu, Marcel G M Wolfs, Patrick Deelen, Harm-Jan Westra, Rudolf S N Fehrmann, Gerard J Te Meerman, Wim A Buurman, Sander S M Rensen, Harry J M Groen, Rinse K Weersma, Leonard H van den Berg, Jan Veldink, Roel A Ophoff, Harold Snieder, David van Heel, Ritsert C Jansen, Marten H Hofker, Cisca Wijmenga, Lude Franke
Published 2012-01-01

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

by Rian M Nijmeijer, Raffaella M Gadaleta, Saskia W C van Mil, Adriaan A van Bodegraven, J Bart A Crusius, Gerard Dijkstra, Daan W Hommes, Dirk J de Jong, Pieter C F Stokkers, Hein W Verspaget, Rinse K Weersma, C Janneke van der Woude, Janneke M Stapelbroek, Marguerite E I Schipper, Cisca Wijmenga, Karel J van Erpecum, Bas Oldenburg, Dutch Initiative on Crohn, Colitis (ICC)
Published 2011-01-01

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

by Marijn C Visschedijk, Rudi Alberts, Soren Mucha, Patrick Deelen, Dirk J de Jong, Marieke Pierik, Lieke M Spekhorst, Floris Imhann, Andrea E van der Meulen-de Jong, C Janneke van der Woude, Adriaan A van Bodegraven, Bas Oldenburg, Mark Löwenberg, Gerard Dijkstra, David Ellinghaus, Stefan Schreiber, Cisca Wijmenga, Initiative on Crohn and Colitis, Parelsnoer Institute, Manuel A Rivas, Andre Franke, Cleo C van Diemen, Rinse K Weersma
Published 2016-01-01

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

by Rudolf S N Fehrmann, Ritsert C Jansen, Jan H Veldink, Harm-Jan Westra, Danny Arends, Marc Jan Bonder, Jingyuan Fu, Patrick Deelen, Harry J M Groen, Asia Smolonska, Rinse K Weersma, Robert M W Hofstra, Wim A Buurman, Sander Rensen, Marcel G M Wolfs, Mathieu Platteel, Alexandra Zhernakova, Clara C Elbers, Eleanora M Festen, Gosia Trynka, Marten H Hofker, Christiaan G J Saris, Roel A Ophoff, Leonard H van den Berg, David A van Heel, Cisca Wijmenga, Gerard J Te Meerman, Lude Franke
Published 2011-08-01

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

by Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, The International IBD Genetics Consortium, Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges
Published 2018-06-01