Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men.

by Zoltán Bochdanovits, David Sondervan, Sophie Perillous, Toos van Beijsterveldt, Dorret Boomsma, Peter Heutink
Published 2008-02-01

Comprehensive mRNA expression profiling distinguishes tauopathies and identifies shared molecular pathways.

by Iraad F Bronner, Zoltán Bochdanovits, Patrizia Rizzu, Wouter Kamphorst, Rivka Ravid, John C van Swieten, Peter Heutink
Published 2009-08-01

Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.

by Javier Simón-Sánchez, Harro Seelaar, Zoltán Bochdanovits, Dorly J H Deeg, John C van Swieten, Peter Heutink
Published 2009-01-01

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening

by Ibrahim Boussaad, Gérald Cruciani, Silvia Bolognin, Paul Antony, Claire M. Dording, Yong-Jun Kwon, Peter Heutink, Eugenio Fava, Jens C. Schwamborn, Rejko Krüger
Published 2021-01-01

Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21–22

by Armand Savioz, Beat M Riederer, Peter Heutink, Patrizia Rizzu, Markus Tolnay, Enikö Kövari, Alphonse Probst, I.rène M Riederer, Constantin Bouras, Geneviève Leuba
Published 2003-02-01

iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression

by Tabea Strauß, Tabea Strauß, Amir Marvian-Tayaranian, Amir Marvian-Tayaranian, Eldem Sadikoglou, Ashutosh Dhingra, Florian Wegner, Florian Wegner, Dietrich Trümbach, Wolfgang Wurst, Wolfgang Wurst, Wolfgang Wurst, Peter Heutink, Peter Heutink, Sigrid C. Schwarz, Sigrid C. Schwarz, Sigrid C. Schwarz, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger
Published 2021-08-01

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.

by Anke A Dijkstra, Angela Ingrassia, Renee X de Menezes, Ronald E van Kesteren, Annemieke J M Rozemuller, Peter Heutink, Wilma D J van de Berg
Published 2015-01-01

<i>PLA2G6</i> Mutations Related to Distinct Phenotypes: A New Case with Early-onset Parkinsonism

by Anamika Giri, Gamze Guven, Hasmet Hanagasi, Ann-Kathrin Hauser, Nihan Erginul-Unaltuna, Basar Bilgic, Hakan Gurvit, Peter Heutink, Thomas Gasser, Ebba Lohmann, Javier Simón-Sánchez
Published 2016-03-01

Trehalose improves human fibroblast deficits in a new CHIP-mutation related ataxia.

by Maria Jose Casarejos, Juan Perucho, Jose Luis López-Sendón, Justo García de Yébenes, Conceição Bettencourt, Ana Gómez, Carolina Ruiz, Peter Heutink, Patrizia Rizzu, Maria Angeles Mena
Published 2014-01-01

FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.

by Thais S Rizzi, Sophie van der Sluis, Catherine Derom, Evert Thiery, Ronald E van Kesteren, Nele Jacobs, Sofie Van Gestel, Robert Vlietinck, Matthijs Verhage, Peter Heutink, Danielle Posthuma
Published 2013-01-01

Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.

by Gamze Guven, Ebba Lohmann, Jose Bras, J Raphael Gibbs, Hakan Gurvit, Basar Bilgic, Hasmet Hanagasi, Patrizia Rizzu, Peter Heutink, Murat Emre, Nihan Erginel-Unaltuna, Walter Just, John Hardy, Andrew Singleton, Rita Guerreiro
Published 2016-01-01

Resequencing three candidate genes for major depressive disorder in a Dutch cohort.

by Eva C Verbeek, Marianna R Bevova, Zoltán Bochdanovits, Patrizia Rizzu, Ingrid M C Bakker, Tiny Uithuisje, Eco J De Geus, Johannes H Smit, Brenda W Penninx, Dorret I Boomsma, Witte J G Hoogendijk, Peter Heutink
Published 2013-01-01

A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder.

by Eva C Verbeek, Ingrid M C Bakker, Marianna R Bevova, Zoltán Bochdanovits, Patrizia Rizzu, David Sondervan, Gonneke Willemsen, Eco J de Geus, Johannes H Smit, Brenda W Penninx, Dorret I Boomsma, Witte J G Hoogendijk, Peter Heutink
Published 2012-01-01

Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.

by Javier Simón-Sánchez, Laura L Kilarski, Michael A Nalls, Maria Martinez, Claudia Schulte, Peter Holmans, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Thomas Gasser, John Hardy, Andrew B Singleton, Nicholas W Wood, Alexis Brice, Peter Heutink, Nigel Williams, Huw R Morris
Published 2012-01-01

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

by Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Published 2013-01-01

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

by J Kenneth Baillie, Andrew Bretherick, Christopher S Haley, Sara Clohisey, Alan Gray, Lucile P A Neyton, Jeffrey Barrett, Eli A Stahl, Albert Tenesa, Robin Andersson, J Ben Brown, Geoffrey J Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, IIBDGC Consortium, Damian Mole, Vladimir B Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Harukazu Suzuki, Jack Satsangi, Christine A Wells, Nir Hacohen, Thomas C Freeman, Yoshihide Hayashizaki, Piero Carninci, Alistair R R Forrest, David A Hume
Published 2018-03-01

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

by Christina M Lill, Johannes T Roehr, Matthew B McQueen, Fotini K Kavvoura, Sachin Bagade, Brit-Maren M Schjeide, Leif M Schjeide, Esther Meissner, Ute Zauft, Nicole C Allen, Tian Liu, Marcel Schilling, Kari J Anderson, Gary Beecham, Daniela Berg, Joanna M Biernacka, Alexis Brice, Anita L DeStefano, Chuong B Do, Nicholas Eriksson, Stewart A Factor, Matthew J Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A Hardy, Peter Heutink, Erin M Hill-Burns, Christine Klein, Jeanne C Latourelle, Demetrius M Maraganore, Eden R Martin, Maria Martinez, Richard H Myers, Michael A Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K Scott, Manu Sharma, Andrew B Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y Tung, Jeffery Vance, Nick W Wood, Cyrus P Zabetian, 23andMe Genetic Epidemiology of Parkinson's Disease Consortium, International Parkinson's Disease Genomics Consortium, Parkinson's Disease GWAS Consortium, Wellcome Trust Case Control Consortium 2), Peter Young, Rudolph E Tanzi, Muin J Khoury, Frauke Zipp, Hans Lehrach, John P A Ioannidis, Lars Bertram
Published 2012-01-01

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

by Lea K Davis, Dongmei Yu, Clare L Keenan, Eric R Gamazon, Anuar I Konkashbaev, Eske M Derks, Benjamin M Neale, Jian Yang, S Hong Lee, Patrick Evans, Cathy L Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrio, Oscar J Bienvenu, Michael H Bloch, Rianne M Blom, Ruth D Bruun, Cathy L Budman, Beatriz Camarena, Desmond Campbell, Carolina Cappi, Julio C Cardona Silgado, Danielle C Cath, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, David V Conti, Edwin H Cook, Vladimir Coric, Bernadette A Cullen, Dieter Deforce, Richard Delorme, Yves Dion, Christopher K Edlund, Karin Egberts, Peter Falkai, Thomas V Fernandez, Patience J Gallagher, Helena Garrido, Daniel Geller, Simon L Girard, Hans J Grabe, Marco A Grados, Benjamin D Greenberg, Varda Gross-Tsur, Stephen Haddad, Gary A Heiman, Sian M J Hemmings, Ana G Hounie, Cornelia Illmann, Joseph Jankovic, Michael A Jenike, James L Kennedy, Robert A King, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L Lowe, Fabio Macciardi, James T McCracken, Lauren M McGrath, Sandra C Mesa Restrepo, Rainald Moessner, Jubel Morgan, Heike Muller, Dennis L Murphy, Allan L Naarden, William Cornejo Ochoa, Roel A Ophoff, Lisa Osiecki, Andrew J Pakstis, Michele T Pato, Carlos N Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias J Renner, Victor I Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, Maria C Rosàrio, David Rosenberg, Guy A Rouleau, Stephan Ruhrmann, Andres Ruiz-Linares, Aline S Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey S Singer, Jan H Smit, Dan J Stein, E Strengman, Jay A Tischfield, Ana V Valencia Duarte, Homero Vallada, Filip Van Nieuwerburgh, Jeremy Veenstra-Vanderweele, Susanne Walitza, Ying Wang, Jens R Wendland, Herman G M Westenberg, Yin Yao Shugart, Euripedes C Miguel, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L Hanna, Peter Heutink, Damiaan Denys, Paul D Arnold, Ben A Oostra, Gerald Nestadt, Nelson B Freimer, David L Pauls, Naomi R Wray, S Evelyn Stewart, Carol A Mathews, James A Knowles, Nancy J Cox, Jeremiah M Scharf
Published 2013-10-01