Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman´s Photometric Method

by Kamil Kuca, Martina Hrabinova, Miroslav Pohanka
Published 2008-09-01

Assessment of Acetylcholinesterase Activity Using Indoxylacetate and Comparison with the Standard Ellman’s Method

by Kamil Kuca, Miroslav Pohanka, Martina Hrabinova, Jean-Pierre Simonato
Published 2011-04-01

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vit...

by Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová
Published 2005-01-01

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms

by Jana Zdarova-Karasova, Martina Hrabinova, Kamil Kuca, Ladislav Novotný, Jan Misík, Miroslav Pohanka
Published 2009-05-01

Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain

by Daniel Jun, Martina Hrabinova, Petra Hanusova, Kamil Musilek, Petr Stodulka, Jan Marek, Kamil Kuca
Published 2007-10-01

Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator

by Jan Marek, Martina Hrabinova, Petr Stodulka, Daniel Jun, Martin Paar, Kamil Musilek, Kamil Kuca
Published 2007-08-01

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae)

by Tomáš Siatka, Markéta Adamcová, Lubomír Opletal, Lucie Cahlíková, Daniel Jun, Martina Hrabinová, Jiří Kuneš, Jakub Chlebek
Published 2017-07-01

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

by Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova
Published 2009-12-01

Amaryllidaceae Alkaloids of Belladine-Type from <i>Narcissus pseudonarcissus</i> cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

by Abdullah Al Mamun, Jana Maříková, Daniela Hulcová, Jiří Janoušek, Marcela Šafratová, Lucie Nováková, Tomáš Kučera, Martina Hrabinová, Jiří Kuneš, Jan Korábečný, Lucie Cahlíková
Published 2020-05-01

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

by Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny
Published 2019-08-01

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

by Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Published 2019-04-01

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

by Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França
Published 2018-05-01

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

by Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuca
Published 2015-12-01

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease

by Eliška Kohelová, Rozálie Peřinová, Negar Maafi, Jan Korábečný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Loreto Martínez González, Martina Hrabinova, Katarina Vorčáková, Lucie Nováková, Angela De Simone, Radim Havelek, Lucie Cahlíková
Published 2019-04-01

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-d-Aspartate Receptor Antagonists

by Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Published 2021-12-01

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

by Monika Schmidt, Ondrej Benek, Lucie Vinklarova, Martina Hrabinova, Lucie Zemanova, Matej Chribek, Vendula Kralova, Lukas Hroch, Rafael Dolezal, Antonin Lycka, Lukas Prchal, Daniel Jun, Laura Aitken, Frank Gunn-Moore, Kamil Kuca, Kamil Musilek
Published 2020-03-01

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

by Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuca
Published 2017-07-01

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

by Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho
Published 2018-02-01

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Do...

by Abdullah Al Mamun, Filip Pidaný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Monika Schmidt, Maria Carmen Catapano, Martina Hrabinová, Daniel Jun, Lubica Múčková, Jiří Kuneš, Jiří Janoušek, Rudolf Andrýs, Lucie Nováková, Rozálie Peřinová, Negar Maafi, Ondřej Soukup, Jan Korábečný, Lucie Cahlíková
Published 2021-08-01