1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

by Ondrej Benek, Lukas Hroch, Laura Aitken, Frank Gunn-Moore, Lucie Vinklarova, Kamil Kuca, Daniel I. Perez, Concepcion Perez, Ana Martinez, Zdenek Fisar, Kamil Musilek
Published 2018-01-01

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease

by Qing Yu, Yongfu Wang, Fang Du, Shijun Yan, Gang Hu, Nicola Origlia, Grazia Rutigliano, Qinru Sun, Haiyang Yu, James Ainge, Shi Fang Yan, Frank Gunn-Moore, Shirley ShiDu Yan
Published 2018-07-01

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

by Monika Schmidt, Ondrej Benek, Lucie Vinklarova, Martina Hrabinova, Lucie Zemanova, Matej Chribek, Vendula Kralova, Lukas Hroch, Rafael Dolezal, Antonin Lycka, Lukas Prchal, Daniel Jun, Laura Aitken, Frank Gunn-Moore, Kamil Kuca, Kamil Musilek
Published 2020-03-01

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.

by Pavitra Purohit, Francesc Perez-Branguli, Iryna Prots, Eva Borger, Frank Gunn-Moore, Oliver Welzel, Kristina Loy, Eva Maria Wenzel, Teja W Grömer, Sebastian Brachs, Max Holzer, Rolf Buslei, Kristin Fritsch, Martin Regensburger, Konrad J Böhm, Beate Winner, Dirk Mielenz
Published 2014-01-01