Cholinesterase Research

by Jan Korabecny, Ondrej Soukup
Published 2021-07-01

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

by Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin
Published 2009-01-01

Enzymatic Degradation of Organophosphorus Pesticides and Nerve Agents by EC: 3.1.8.2

by Marek Matula, Tomas Kucera, Ondrej Soukup, Jaroslav Pejchal
Published 2020-11-01

Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts

by Jan Marek, David Malinak, Rafael Dolezal, Ondrej Soukup, Marketa Pasdiorova, Martin Dolezal, Kamil Kuca
Published 2015-02-01

Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent

by Kamil Musilek, Jan Korabecny, Miroslav Pohanka, Ondrej Soukup, Jiri Cabal, Petr Stodulka, Jan Marek, Kamil Kuca
Published 2010-03-01

Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain

by Kamil Kuca, Kallol K. Ghosh, Kamil Musilek, Jiri Cabal, Petr Stodulka, Ondrej Soukup, Vladimir Buchta, Jan Marek
Published 2012-05-01

7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

by Kamil Kuca, Katarina Siposova, Lucie Drtinova, Zuzana Gazova, Ondrej Soukup, Kamil Musilek, Anna Horova, Katarina Spilovska, Jan Korabecny, Jan Kral
Published 2013-02-01

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

by Jan Zitko, Barbora Servusová, Pavla Paterová, Jana Mandíková, Vladimír Kubíček, Radim Kučera, Veronika Hrabcová, Jiří Kuneš, Ondřej Soukup, Martin Doležal
Published 2013-12-01

Profiling donepezil template into multipotent hybrids with antioxidant properties

by Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Published 2018-01-01

Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts

by Aneta Markova, Michaela Hympanova, Marek Matula, Lukas Prchal, Radek Sleha, Marketa Benkova, Lenka Pulkrabkova, Ondrej Soukup, Zuzana Krocova, Daniel Jun, Jan Marek
Published 2021-09-01

Wide-Antimicrobial Spectrum of Picolinium Salts

by Sarka Salajkova, Marketa Benkova, Jan Marek, Radek Sleha, Lukas Prchal, David Malinak, Rafael Dolezal, Kristina Sepčić, Nina Gunde-Cimerman, Kamil Kuca, Ondrej Soukup
Published 2020-05-01

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

by Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny
Published 2019-08-01

Investigation of New Orexin 2 Receptor Modulators Using <i>In Silico</i> and In Vitro Methods

by Jana Janockova, Rafael Dolezal, Eugenie Nepovimova, Tereza Kobrlova, Marketa Benkova, Kamil Kuca, Jan Konecny, Eva Mezeiova, Michaela Melikova, Vendula Hepnarova, Avi Ring, Ondrej Soukup, Jan Korabecny
Published 2018-11-01

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

by Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuca
Published 2015-12-01

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D₂ 3,4-dihydroquinolin-2(1<i>H</i>)-one Derivatives Related to Aripiprazole

by Radomir Juza, Kristyna Stefkova, Wim Dehaen, Alena Randakova, Tomas Petrasek, Iveta Vojtechova, Tereza Kobrlova, Lenka Pulkrabkova, Lubica Muckova, Marko Mecava, Lukas Prchal, Eva Mezeiova, Kamil Musilek, Ondrej Soukup, Jan Korabecny
Published 2021-08-01

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-d-Aspartate Receptor Antagonists

by Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Published 2021-12-01

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

by Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Published 2019-01-01

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

by Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Published 2016-05-01

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

by Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Published 2019-01-01

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

by Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuca
Published 2017-07-01