Improved selection of participants in genetic longevity studies: family scores revisited

by Mar Rodríguez-Girondo, Niels van den Berg, Michel H. Hof, Marian Beekman, Eline Slagboom
Published 2021-01-01

Lipoprotein particle profiles mark familial and sporadic human longevity.

by Bastiaan T Heijmans, Marian Beekman, Jeanine J Houwing-Duistermaat, Mark R Cobain, Jonathan Powell, Gerard Jan Blauw, Frans van der Ouderaa, Rudi G J Westendorp, P Eline Slagboom
Published 2006-12-01

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

by Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, Rick J. Mourits, Kees Mandemakers, Angelique A. P. O. Janssens, Marian Beekman, Ken R. Smith, P. Eline Slagboom
Published 2019-01-01

Classification for longevity potential: the use of novel biomarkers

by Marian Beekman, Hae-Won Uh, Diana Van Heemst, Manfred Wuhrer, L. Renee Ruhaak, Vanessa Gonzalez-Covarrubias, Vanessa Gonzalez-Covarrubias, Thomas Hankemeier, Thomas Hankemeier, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom
Published 2016-10-01

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.

by L Renee Ruhaak, Hae-Won Uh, Marian Beekman, Carolien A M Koeleman, Cornelis H Hokke, Rudi G J Westendorp, Manfred Wuhrer, Jeanine J Houwing-Duistermaat, P Eline Slagboom, André M Deelder
Published 2010-09-01

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

by Sabrina van der Kroef, Raymond Noordam, Joris Deelen, Abimbola A Akintola, Steffy W M Jansen, Iris Postmus, Carolien A Wijsman, Marian Beekman, Simon P Mooijaart, P Eline Slagboom, Diana van Heemst
Published 2016-01-01

Homocysteine and familial longevity: the Leiden Longevity Study.

by Carolien A Wijsman, Diana van Heemst, Maarten P Rozing, P Eline Slagboom, Marian Beekman, Anton J M de Craen, Andrea B Maier, Rudi G J Westendorp, Henk J Blom, Simon P Mooijaart
Published 2011-03-01

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes

by Raymond Noordam, Neline C. Huurman, Carolien A. Wijsman, Abimbola A. Akintola, Steffy W. M. Jansen, Stephanie Stassen, Stephanie Stassen, Marian Beekman, Ondine van de Rest, P. Eline Slagboom, Simon P. Mooijaart, Simon P. Mooijaart, Diana van Heemst
Published 2018-05-01

Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference

by Elisa Benedetti, Nathalie Gerstner, Maja Pučić-Baković, Toma Keser, Karli R. Reiding, L. Renee Ruhaak, Tamara Štambuk, Maurice H. J. Selman, Igor Rudan, Ozren Polašek, Caroline Hayward, Marian Beekman, Eline Slagboom, Manfred Wuhrer, Malcolm G. Dunlop, Gordan Lauc, Jan Krumsiek
Published 2020-07-01

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

by Raymond Noordam, Debbie Vermond, Debbie Vermond, Hermijntje Drenth, Hermijntje Drenth, Carolien A. Wijman, Abimbola A. Akintola, Sabrina van der Kroef, Steffy W. M. Jansen, Neline C. Huurman, Bianca A. M. Schutte, Marian Beekman, P. Eline Slagboom, Simon P. Mooijaart, Simon P. Mooijaart, Diana van Heemst
Published 2017-09-01

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R

by Willemijn M. Passtoors, Judith M. Boer, Jelle J. Goeman, Erik B. van den Akker, Joris Deelen, Bas J. Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H. A. M. Vossen, Jeanine J. Houwing-Duistermaat, Gert Jan B. van Ommen, Rudi G. J. Westendorp, Diana van Heemst, Anton J. M. de Craen, Andrew J. White, David A. Gunn, Marian Beekman, P. Eline Slagboom
Published 2012-01-01

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.

by Willemijn M Passtoors, Judith M Boer, Jelle J Goeman, Erik B van den Akker, Joris Deelen, Bas J Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H A M Vossen, Jeanine J Houwing-Duistermaat, Gert Jan B van Ommen, Rudi G J Westendorp, Diana van Heemst, Anton J M de Craen, Andrew J White, David A Gunn, Marian Beekman, P Eline Slagboom
Published 2012-01-01

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for and.

by Willemijn M. Passtoors, Judith M. Boer, Jelle J. Goeman, Erik B. van den Akker, Joris Deelen, Bas J. Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H. A. M. Vossen, Jeanine J. Houwing-Duistermaat, Gert Jan B. van Ommen, Rudi G. J. Westendorp, Diana van Heemst, Anton J. M. de Craen, Andrew J. White, David A. Gunn, Marian Beekman, P. Eline Slagboom
Published 2012-01-01

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-03-01

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, Harmen H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-01-01

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

by Annika Wahl, Annika Wahl, Erik van den Akker, Erik van den Akker, Lucija Klaric, Lucija Klaric, Lucija Klaric, Jerko Štambuk, Elisa Benedetti, Rosina Plomp, Genadij Razdorov, Irena Trbojević-Akmačić, Joris Deelen, Joris Deelen, Diana van Heemst, P. Eline Slagboom, Frano Vučković, Harald Grallert, Harald Grallert, Harald Grallert, Jan Krumsiek, Jan Krumsiek, Konstantin Strauch, Konstantin Strauch, Annette Peters, Thomas Meitinger, Caroline Hayward, Manfred Wuhrer, Marian Beekman, Gordan Lauc, Gordan Lauc, Christian Gieger, Christian Gieger
Published 2018-02-01

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

by Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom
Published 2019-08-01

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

by Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan
Published 2013-01-01

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

by Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemans, Chunyu Liu, Allan F McRae, Michael M Mendelson, Martina Müller-Nurasyid, Annette Peters, P Eline Slagboom, John M Starr, David-Alexandre Trégouët, André G Uitterlinden, Marleen M J van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S Wells, Chen Yao, Ian J Deary, France Gagnon, Bastiaan T Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G Heil, Joyce B J van Meurs, CHARGE Consortium Epigenetics group and BIOS Consortium
Published 2017-01-01

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

by Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen H.M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman, Joris Deelen, Ko Willems van Dijk, Tõnu Esko, Jouke-Jan Hottenga, Elisabeth M van Leeuwen, Terho Lehtimäki, Evelin Mihailov, Richard J. Rose, Anton J.M. de Craen, Christian Gieger, Mika Kähönen, Markus Perola, Stefan Blankenberg, Markku J. Savolainen, Aswin Verhoeven, Jorma Viikari, Gonneke Willemsen, Dorret I. Boomsma, Cornelia M. van Duijn, Johan Eriksson, Antti Jula, Marjo-Riitta Järvelin, Jaakko Kaprio, Andres Metspalu, Olli Raitakari, Veikko Salomaa, P. Eline Slagboom, Melanie Waldenberger, Samuli Ripatti, Mika Ala-Korpela
Published 2016-03-01