Monogenic Diabetes Modeling: In Vitro Pancreatic Differentiation From Human Pluripotent Stem Cells Gains Momentum

by Juan Ignacio Burgos, Ludovic Vallier, Santiago A. Rodríguez-Seguí
Published 2021-07-01

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells

by Loriana Vitillo, Catherine Durance, Zoe Hewitt, Harry Moore, Austin Smith, Ludovic Vallier
Published 2020-09-01

Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas.

by Maria João Lima, Hilary M Docherty, Yuanxiao Chen, Ludovic Vallier, Kevin Docherty
Published 2012-01-01

International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper

by Filipa A.C. Soares, Michael Sheldon, Mahendra Rao, Christine Mummery, Ludovic Vallier
Published 2014-12-01

Genetic background drives transcriptional variation in human induced pluripotent stem cells.

by Foad Rouhani, Natsuhiko Kumasaka, Miguel Cardoso de Brito, Allan Bradley, Ludovic Vallier, Daniel Gaffney
Published 2014-06-01

Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes

by Matthias Pawlowski, Daniel Ortmann, Alessandro Bertero, Joana M. Tavares, Roger A. Pedersen, Ludovic Vallier, Mark R.N. Kotter
Published 2017-04-01

Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation

by Giovanni Canu, Emmanouil Athanasiadis, Rodrigo A. Grandy, Jose Garcia-Bernardo, Paulina M. Strzelecka, Ludovic Vallier, Daniel Ortmann, Ana Cvejic
Published 2020-07-01

Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.

by Amanda L Evans, Tiago Faial, Michael J Gilchrist, Thomas Down, Ludovic Vallier, Roger A Pedersen, Fiona C Wardle, James C Smith
Published 2012-01-01

Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic ste...

by Giuseppe Lupo, Claire Novorol, Joseph R. Smith, Ludovic Vallier, Elena Miranda, Morgan Alexander, Stefano Biagioni, Roger A. Pedersen, William A. Harris
Published 2013-01-01

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

by Foad J Rouhani, Serena Nik-Zainal, Arthur Wuster, Yilong Li, Nathalie Conte, Hiroko Koike-Yusa, Natsuhiko Kumasaka, Ludovic Vallier, Kosuke Yusa, Allan Bradley
Published 2016-04-01

Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways.

by Ludovic Vallier, Thomas Touboul, Zhenzhi Chng, Minodora Brimpari, Nicholas Hannan, Enrique Millan, Lucy E Smithers, Matthew Trotter, Peter Rugg-Gunn, Anne Weber, Roger A Pedersen
Published 2009-06-01

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.

by Richard L Gieseck, Nicholas R F Hannan, Roque Bort, Neil A Hanley, Rosemary A L Drake, Grant W W Cameron, Thomas A Wynn, Ludovic Vallier
Published 2014-01-01

Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr

by Chukwuma A. Agu, Filipa A.C. Soares, Alex Alderton, Minal Patel, Rizwan Ansari, Sharad Patel, Sally Forrest, Fengtang Yang, Jonathan Lineham, Ludovic Vallier, Christopher M. Kirton
Published 2015-10-01

Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

by Lee M. Butcher, Mitsuteru Ito, Minodora Brimpari, Tiffany J. Morris, Filipa A. C. Soares, Lars Ährlund-Richter, Nessa Carey, Ludovic Vallier, Anne C. Ferguson-Smith, Stephan Beck
Published 2016-01-01

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

by Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Published 2019-02-01

Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos

by Rachel E. Jennings, Andrew A. Berry, David T. Gerrard, Stephen J. Wearne, James Strutt, Sarah Withey, Mariya Chhatriwala, Karen Piper Hanley, Ludovic Vallier, Nicoletta Bobola, Neil A. Hanley
Published 2017-11-01

An in vitro stem cell model of human epiblast and yolk sac interaction

by Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz
Published 2021-08-01

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

by Crystal Y. Chia, Pedro Madrigal, Simon L.I.J. Denil, Iker Martinez, Jose Garcia-Bernardo, Ranna El-Khairi, Mariya Chhatriwala, Maggie H. Shepherd, Andrew T. Hattersley, N. Ray Dunn, Ludovic Vallier
Published 2019-01-01

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

by Natasha Hui Jin Ng, Joanita Binte Jasmen, Chang Siang Lim, Hwee Hui Lau, Vidhya Gomathi Krishnan, Juned Kadiwala, Rohit N. Kulkarni, Helge Ræder, Ludovic Vallier, Shawn Hoon, Adrian Kee Keong Teo
Published 2019-06-01

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

by Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Published 2021-08-01