Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation

by Julian R. Peat, Wendy Dean, Stephen J. Clark, Felix Krueger, Sébastien A. Smallwood, Gabriella Ficz, Jong Kyoung Kim, John C. Marioni, Timothy A. Hore, Wolf Reik
Published 2014-12-01

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

by Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Published 2019-02-01

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

by Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Published 2018-02-01

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

by Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias
Published 2021-10-01