Computer modeling describes gravity-related adaptation in cell cultures.

by Ludmil B Alexandrov, Stoyana Alexandrova, Anny Usheva
Published 2009-12-01

Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator

by Erik N. Bergstrom, Mark Barnes, Iñigo Martincorena, Ludmil B. Alexandrov
Published 2020-10-01

Nonnegative/Binary matrix factorization with a D-Wave quantum annealer.

by Daniel O'Malley, Velimir V Vesselinov, Boian S Alexandrov, Ludmil B Alexandrov
Published 2018-01-01

Deciphering Signatures of Mutational Processes Operative in Human Cancer

by Ludmil B. Alexandrov, Serena Nik-Zainal, David C. Wedge, Peter J. Campbell, Michael R. Stratton
Published 2013-01-01

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

by Erik N. Bergstrom, Mi Ni Huang, Uma Mahto, Mark Barnes, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov
Published 2019-08-01

Strength of immune selection in tumors varies with sex and age

by Andrea Castro, Rachel Marty Pyke, Xinlian Zhang, Wesley Kurt Thompson, Chi-Ping Day, Ludmil B. Alexandrov, Maurizio Zanetti, Hannah Carter
Published 2020-08-01

Correction: DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases

by Boian S. Alexandrov, Vlad I. Valtchinov, Ludmil B. Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S. Kohane, Kim Ø. Rasmussen, Alan R. Bishop, Anny Usheva
Published 2011-01-01

DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases.

by Boian S Alexandrov, Vlad I Valtchinov, Ludmil B Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S Kohane, Kim Ø Rasmussen, Alan R Bishop, Anny Usheva
Published 2011-01-01

Correction: DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases.

by Boian S. Alexandrov, Vlad I. Valtchinov, Ludmil B. Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S. Kohane, Kim Ø. Rasmussen, Alan R. Bishop, Anny Usheva
Published 2011-01-01

Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics.

by Kristy Nowak-Lovato, Ludmil B Alexandrov, Afsheen Banisadr, Amy L Bauer, Alan R Bishop, Anny Usheva, Fangping Mu, Elizabeth Hong-Geller, Kim Ø Rasmussen, William S Hlavacek, Boian S Alexandrov
Published 2013-01-01

Germline MC1R status influences somatic mutation burden in melanoma

by Carla Daniela Robles-Espinoza, Nicola D. Roberts, Shuyang Chen, Finbarr P. Leacy, Ludmil B. Alexandrov, Natapol Pornputtapong, Ruth Halaban, Michael Krauthammer, Rutao Cui, D. Timothy Bishop, David J. Adams
Published 2016-07-01

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

by Yun Rose Li, Kyle D. Halliwill, Cassandra J. Adams, Vivek Iyer, Laura Riva, Rashid Mamunur, Kuang-Yu Jen, Reyno del Rosario, Erik Fredlund, Gillian Hirst, Ludmil B. Alexandrov, David Adams, Allan Balmain
Published 2020-01-01

Mammalian stem cells reprogramming in response to terahertz radiation.

by Jonathan Bock, Yayoi Fukuyo, Sona Kang, M Lisa Phipps, Ludmil B Alexandrov, Kim Ø Rasmussen, Alan R Bishop, Evan D Rosen, Jennifer S Martinez, Hou-Tong Chen, George Rodriguez, Boian S Alexandrov, Anny Usheva
Published 2010-12-01

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

by Lene Alsøe, Antonio Sarno, Sergio Carracedo, Diana Domanska, Felix Dingler, Lisa Lirussi, Tanima SenGupta, Nuriye Basdag Tekin, Laure Jobert, Ludmil B. Alexandrov, Anastasia Galashevskaya, Cristina Rada, Geir Kjetil Sandve, Torbjørn Rognes, Hans E. Krokan, Hilde Nilsen
Published 2017-08-01

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

by Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Published 2018-09-01

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

by Zhiyong Wang, Victoria H. Wu, Michael M. Allevato, Mara Gilardi, Yudou He, Juan Luis Callejas-Valera, Lynn Vitale-Cross, Daniel Martin, Panomwat Amornphimoltham, James Mcdermott, Bryan S. Yung, Yusuke Goto, Alfredo A. Molinolo, Andrew B. Sharabi, Ezra E. W. Cohen, Qianming Chen, J. Guy Lyons, Ludmil B. Alexandrov, J. Silvio Gutkind
Published 2019-12-01

A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer

by Alessandra Viel, Alessandro Bruselles, Ettore Meccia, Mara Fornasarig, Michele Quaia, Vincenzo Canzonieri, Eleonora Policicchio, Emanuele Damiano Urso, Marco Agostini, Maurizio Genuardi, Emanuela Lucci-Cordisco, Tiziana Venesio, Aline Martayan, Maria Grazia Diodoro, Lupe Sanchez-Mete, Vittoria Stigliano, Filomena Mazzei, Francesca Grasso, Alessandro Giuliani, Marta Baiocchi, Roberta Maestro, Giuseppe Giannini, Marco Tartaglia, Ludmil B. Alexandrov, Margherita Bignami
Published 2017-06-01

Timing the initiation of multiple myeloma

by Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias Campo, Reiner Siebert, Herve Avet-Loiseau, Ola Landgren, Nikhil Munshi, Peter J. Campbell, Francesco Maura
Published 2020-04-01

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

by Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R. Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B. Alexandrov, Kevin M. Brown, David C. Wedge, Stephen Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi
Published 2020-06-01

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

by Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Published 2019-04-01