Structural insights into TSC complex assembly and GAP activity on Rheb

by Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
Published 2021-01-01

CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

by Peng Liu, Jin-Pin Liu, Si-Jia Sun, Yun Gao, Yingjie Ai, Xiufei Chen, Yiping Sun, Mengyu Zhou, Yun Liu, Yue Xiong, Hai-Xin Yuan
Published 2021-07-01

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

by Jenna L Jewell, Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor, Kun-Liang Guan
Published 2019-05-01

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

by Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan
Published 2018-02-01