Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

by Moataz Abdalkader, Riikka Lampinen, Katja M. Kanninen, Tarja M. Malm, Jeffrey R. Liddell
Published 2018-07-01

Long-Term Exercise Protects against Cellular Stresses in Aged Mice

by Irina Belaya, Masataka Suwa, Tao Chen, Rashid Giniatullin, Katja M. Kanninen, Mustafa Atalay, Shuzo Kumagai
Published 2018-01-01

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

by Elena Puris, Štěpán Kouřil, Lukáš Najdekr, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, David Friedecký, Mikko Gynther
Published 2021-06-01

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

by Hiramani Dhungana, Mikko T. Huuskonen, Merja Jaronen, Sighild Lemarchant, Humair Ali, Velta Keksa-Goldsteine, Gundars Goldsteins, Katja M. Kanninen, Jari Koistinaho, Tarja Malm
Published 2017-12-01

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

by Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm
Published 2019-06-01

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

by Katja M. Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J. Parker, Grace E. Lidgerwood, Irene Volitakis, George Ganio, Peter J. Crouch, Anthony R. White
Published 2013-05-01

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

by Henri Leinonen, Velta Keksa-Goldsteine, Symantas Ragauskas, Philip Kohlmann, Yajuvinder Singh, Ekaterina Savchenko, Jooseppi Puranen, Tarja Malm, Giedrius Kalesnykas, Jari Koistinaho, Heikki Tanila, Katja M. Kanninen
Published 2017-05-01

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

by Irina Belaya, Nina Kucháriková, Veronika Górová, Kai Kysenius, Dominic J. Hare, Peter J. Crouch, Tarja Malm, Mustafa Atalay, Anthony R. White, Jeffrey R. Liddell, Katja M. Kanninen
Published 2021-08-01

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease

by Irina Belaya, Mariia Ivanova, Annika Sorvari, Marina Ilicic, Sanna Loppi, Hennariikka Koivisto, Alessandra Varricchio, Heikki Tikkanen, Frederick R. Walker, Mustafa Atalay, Tarja Malm, Alexandra Grubman, Heikki Tanila, Katja M. Kanninen
Published 2020-09-01

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

by Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, SinChun Lim, Brett M Paterson, Paul S Donnelly, Peter J Crouch, Anthony R White
Published 2012-01-01

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

by Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Kärkkäinen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R. White, Tarja Malm, Jari Koistinaho, Katja M. Kanninen
Published 2017-09-01

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

by Diane Moujalled, Janine L James, Sarah J Parker, Grace E Lidgerwood, Clare Duncan, Jodi Meyerowitz, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, Alexandra Grubman, Jeffrey R Liddell, Peter J Crouch, Anthony R White
Published 2013-01-01

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

by Natalia Kolosowska, Maria Gotkiewicz, Hiramani Dhungana, Luca Giudice, Rosalba Giugno, Daphne Box, Mikko T. Huuskonen, Paula Korhonen, Flavia Scoyni, Katja M. Kanninen, Seppo Ylä-Herttuala, Tiia A. Turunen, Mikko P. Turunen, Jari Koistinaho, Tarja Malm
Published 2020-06-01

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

by Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M. Polo, Trevor Wilson, Mika Komppula, Teemu Rönkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R. White, Pasi Jalava, Katja M. Kanninen
Published 2020-06-01

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

by Katja M Kanninen, Alexandra Grubman, Jodi Meyerowitz, Clare Duncan, Jiang-Li Tan, Sarah J Parker, Peter J Crouch, Brett M Paterson, James L Hickey, Paul S Donnelly, Irene Volitakis, Imke Tammen, David N Palmer, Anthony R White
Published 2013-01-01

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

by Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana, Mikko T. Huuskonen, Yuriy Pomeshchik, Ekaterina Savchenko, Paula K. Korhonen, Yajuvinder Singh, Sara Wojciechowski, Šárka Lehtonen, Katja M. Kanninen, Tarja Malm, Jouni Sirviö, Anu Muona, Milla Koistinaho, Gundars Goldsteins, Jari Koistinaho
Published 2021-02-01

CuII(atsm) Attenuates Neuroinflammation

by Xin Yi Choo, Xin Yi Choo, Xin Yi Choo, Jeffrey R. Liddell, Jeffrey R. Liddell, Mikko T. Huuskonen, Alexandra Grubman, Alexandra Grubman, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E. Oikari, Clare Duncan, Simon A. James, Simon A. James, Lachlan E. McInnes, David J. Hayne, Paul S. Donnelly, Eveliina Pollari, Suvi Vähätalo, Katarína Lejavová, Mikko I. Kettunen, Tarja Malm, Jari Koistinaho, Jari Koistinaho, Anthony R. White, Anthony R. White, Katja M. Kanninen, Katja M. Kanninen
Published 2018-09-01

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

by Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko, Katja Puttonen, Šárka Lehtonen, Max Gubert Olivé, Anastasia Shakirzyanova, Stina Leskelä, Timo Sarajärvi, Matti Viitanen, Juha O. Rinne, Mikko Hiltunen, Annakaisa Haapasalo, Rashid Giniatullin, Pasi Tavi, Su-Chun Zhang, Katja M. Kanninen, Riikka H. Hämäläinen, Jari Koistinaho
Published 2017-12-01

Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

by Roxana O. Carare, Roxana Aldea, Nivedita Agarwal, Brian J. Bacskai, Ingo Bechman, Delphine Boche, Guojun Bu, Diederik Bulters, Alt Clemens, Scott E. Counts, Mony deLeon, Per K. Eide, Silvia Fossati, Steven M. Greenberg, Edith Hamel, Cheryl A. Hawkes, Maya Koronyo‐Hamaoui, Atticus H. Hainsworth, David Holtzman, Masafumi Ihara, Angela Jefferson, Raj N. Kalaria, Christopher M. Kipps, Katja M. Kanninen, Ville Leinonen, JoAnne McLaurin, Scott Miners, Tarja Malm, James A. R. Nicoll, Fabrizio Piazza, Gesine Paul, Steven M. Rich, Satoshi Saito, Andy Shih, Henrieta Scholtzova, Heather Snyder, Peter Snyder, Finnbogi Rutur Thormodsson, Susanne J. vanVeluw, Roy O. Weller, David J. Werring, Donna Wilcock, Mark R. Wilson, Berislav V. Zlokovic, Ajay Verma
Published 2020-01-01