Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

by Sara Nikseresht, James B.W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Peter J. Crouch
Published 2020-11-01

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain [version 2; peer review: 2 approved]

by Liam M. Koehn, Yifan Huang, Mark D Habgood, Kai Kysenius, Peter J. Crouch, Katarzyna M Dziegielewska, Norman R Saunders
Published 2020-08-01

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage

by Francesca M. Alves, Kai Kysenius, Marissa K. Caldow, Justin P. Hardee, Peter J. Crouch, Scott Ayton, Ashley I. Bush, Gordon S. Lynch, René Koopman
Published 2021-04-01

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.

by Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush
Published 2011-01-01

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

by Katja M. Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J. Parker, Grace E. Lidgerwood, Irene Volitakis, George Ganio, Peter J. Crouch, Anthony R. White
Published 2013-05-01

ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

by Erin J. McAllum, Blaine R. Roberts, James L. Hickey, Theresa N. Dang, Alexandra Grubman, Paul S. Donnelly, Jeffrey R. Liddell, Anthony R. White, Peter J. Crouch
Published 2015-09-01

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

by Irina Belaya, Nina Kucháriková, Veronika Górová, Kai Kysenius, Dominic J. Hare, Peter J. Crouch, Tarja Malm, Mustafa Atalay, Anthony R. White, Jeffrey R. Liddell, Katja M. Kanninen
Published 2021-08-01

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

by Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, Anthony R White
Published 2014-01-01

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.

by Adam K Walker, Kai Y Soo, Vinod Sundaramoorthy, Sonam Parakh, Yi Ma, Manal A Farg, Robyn H Wallace, Peter J Crouch, Bradley J Turner, Malcolm K Horne, Julie D Atkin
Published 2013-01-01

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

by Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, SinChun Lim, Brett M Paterson, Paul S Donnelly, Peter J Crouch, Anthony R White
Published 2012-01-01

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

by Diane Moujalled, Janine L James, Sarah J Parker, Grace E Lidgerwood, Clare Duncan, Jodi Meyerowitz, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, Alexandra Grubman, Jeffrey R Liddell, Peter J Crouch, Anthony R White
Published 2013-01-01

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

by Katja M Kanninen, Alexandra Grubman, Jodi Meyerowitz, Clare Duncan, Jiang-Li Tan, Sarah J Parker, Peter J Crouch, Brett M Paterson, James L Hickey, Paul S Donnelly, Irene Volitakis, Imke Tammen, David N Palmer, Anthony R White
Published 2013-01-01

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model

by Theresa N. T. Dang, Carol Dobson-Stone, Elias N. Glaros, Woojin S. Kim, Marianne Hallupp, Lauren Bartley, Olivier Piguet, John R. Hodges, Glenda M. Halliday, Kay L. Double, Peter R. Schofield, Peter J. Crouch, John B. J. Kwok
Published 2013-09-01

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1 G93A mice with a C57BL/6 background

by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Luke McAlary, Diane Ly, Christen G. Chisholm, Josh Snow, Kara L. Vine, Tim Karl, Fabian Kreilaus, Lachlan E. McInnes, Sara Nikseresht, Paul S. Donnelly, Peter J. Crouch, Justin J. Yerbury
Published 2021-09-01

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

by Jared R. Williams, Emiliano Trias, Pamela R. Beilby, Nathan I. Lopez, Edwin M. Labut, C. Samuel Bradford, Blaine R. Roberts, Erin J. McAllum, Peter J. Crouch, Timothy W. Rhoads, Cliff Pereira, Marjatta Son, Jeffrey L. Elliott, Maria Clara Franco, Alvaro G. Estévez, Luis Barbeito, Joseph S. Beckman
Published 2016-05-01