Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

by Edward Pokrishevsky, Ran Ha Hong, Ian R Mackenzie, Neil R Cashman
Published 2017-01-01

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

by Edward Pokrishevsky, Leslie I Grad, Masoud Yousefi, Jing Wang, Ian R Mackenzie, Neil R Cashman
Published 2012-01-01

Development and validation of a novel dementia of Alzheimer's type (DAT) score based on metabolism FDG-PET imaging

by Karteek Popuri, Rakesh Balachandar, Kathryn Alpert, Donghuan Lu, Mahadev Bhalla, Ian R. Mackenzie, Robin Ging-Yuek Hsiung, Lei Wang, Mirza Faisal Beg
Published 2018-01-01

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

by Ebrima Gibbs, Judith M. Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L. Wellington, Ian R. Mackenzie, Steven S. Plotkin, Johanne M. Kaplan, Neil R. Cashman
Published 2019-07-01

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

by Asad Jan, Brandon Jansonius, Alberto Delaidelli, Forum Bhanshali, Yi Andy An, Nelson Ferreira, Lisa M. Smits, Gian Luca Negri, Jens C. Schwamborn, Poul H. Jensen, Ian R. Mackenzie, Stefan Taubert, Poul H. Sorensen
Published 2018-07-01

Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers

by Karteek Popuri, Emma Dowds, Mirza Faisal Beg, Rakesh Balachandar, Mahadev Bhalla, Claudia Jacova, Adrienne Buller, Penny Slack, Pheth Sengdy, Rosa Rademakers, Dana Wittenberg, Howard H. Feldman, Ian R. Mackenzie, Ging-Yuek R. Hsiung
Published 2018-01-01

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

by Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Published 2021-06-01

Testicular degeneration in Huntington disease

by Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, Ǻsa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt
Published 2007-06-01

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

by Yanwei Wu, Wei Shao, Tiffany W. Todd, Jimei Tong, Mei Yue, Shunsuke Koga, Monica Castanedes-Casey, Ariston L. Librero, Chris W. Lee, Ian R. Mackenzie, Dennis W. Dickson, Yong-Jie Zhang, Leonard Petrucelli, Mercedes Prudencio
Published 2021-08-01

Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

by Sieun Lee, Sieun Lee, Kailun Jiang, Brandon McIlmoyle, Eleanor To, Qinyuan (Alis) Xu, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek R. Hsiung, Brennan D. Eadie, Marinko V. Sarunic, Mirza Faisal Beg, Jing Z. Cui, Joanne A. Matsubara
Published 2020-07-01

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

by Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Published 2020-03-01

Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.

by Nicola J Rutherford, Yong-Jie Zhang, Matt Baker, Jennifer M Gass, Nicole A Finch, Ya-Fei Xu, Heather Stewart, Brendan J Kelley, Karen Kuntz, Richard J P Crook, Jemeen Sreedharan, Caroline Vance, Eric Sorenson, Carol Lippa, Eileen H Bigio, Daniel H Geschwind, David S Knopman, Hiroshi Mitsumoto, Ronald C Petersen, Neil R Cashman, Mike Hutton, Christopher E Shaw, Kevin B Boylan, Bradley Boeve, Neill R Graff-Radford, Zbigniew K Wszolek, Richard J Caselli, Dennis W Dickson, Ian R Mackenzie, Leonard Petrucelli, Rosa Rademakers
Published 2008-09-01