Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

by Steven S. Plotkin, Neil R. Cashman
Published 2020-10-01

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis.

by Justin J. Yerbury, Neil R. Cashman
Published 2020-09-01

From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis

by Leslie I. Grad, Sarah M. Fernando, Neil R. Cashman
Published 2015-05-01

Initial Structural Models of the Aβ42 Dimer from Replica Exchange Molecular Dynamics Simulations

by Nikolay Blinov, Massih Khorvash, David S. Wishart, Neil R. Cashman, Andriy Kovalenko
Published 2017-11-01

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

by Edward Pokrishevsky, Ran Ha Hong, Ian R Mackenzie, Neil R Cashman
Published 2017-01-01

Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics.

by Nahid N Jetha, Valentyna Semenchenko, David S Wishart, Neil R Cashman, Andre Marziali
Published 2013-01-01

Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies.

by Ming-Dong Wang, James Gomes, Neil R Cashman, Julian Little, Daniel Krewski
Published 2014-01-01

Is Creutzfeldt-Jakob Disease Transmitted in Blood?

by Maura N. Ricketts, Neil R. Cashman, Elizabeth E. Stratton, Susie ElSaadany
Published 1997-06-01

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

by Edward Pokrishevsky, Leslie I Grad, Masoud Yousefi, Jing Wang, Ian R Mackenzie, Neil R Cashman
Published 2012-01-01

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases

by Gareth S.A. Wright, Tatiana F. Watanabe, Kangsa Amporndanai, Steven S. Plotkin, Neil R. Cashman, Svetlana V. Antonyuk, S. Samar Hasnain
Published 2020-06-01

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

by Luke McAlary, Luke McAlary, Steven S. Plotkin, Steven S. Plotkin, Justin J. Yerbury, Justin J. Yerbury, Neil R. Cashman
Published 2020-01-01

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

by Luke McAlary, Luke McAlary, Steven S. Plotkin, Steven S. Plotkin, Justin J. Yerbury, Justin J. Yerbury, Neil R. Cashman
Published 2019-11-01

Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach.

by Alain Van Dorsselaer, Christine Carapito, François Delalande, Christine Schaeffer-Reiss, Daniele Thierse, Hélène Diemer, Douglas S McNair, Daniel Krewski, Neil R Cashman
Published 2011-03-01

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.

by Anthony Crown, Luke McAlary, Eric Fagerli, Hilda Brown, Justin J Yerbury, Ahmad Galaleldeen, Neil R Cashman, David R Borchelt, Jacob I Ayers
Published 2020-01-01

Molecular interactions between monoclonal oligomer-specific antibody 5E3 and its amyloid beta cognates.

by Massih Khorvash, Nick Blinov, Carol Ladner-Keay, Jie Lu, Judith M Silverman, Ebrima Gibbs, Yu Tian Wang, Andriy Kovalenko, David Wishart, Neil R Cashman
Published 2020-01-01

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

by Ebrima Gibbs, Judith M. Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L. Wellington, Ian R. Mackenzie, Steven S. Plotkin, Johanne M. Kaplan, Neil R. Cashman
Published 2019-07-01

Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics

by Michèle G. DuVal, Vijaya K. Hinge, Natalie Snyder, Richard Kanyo, Jenna Bratvold, Edward Pokrishevsky, Neil R. Cashman, Nikolay Blinov, Andriy Kovalenko, W. Ted Allison
Published 2019-04-01

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

by Luke McAlary, Luke McAlary, Yee Lian Chew, Yee Lian Chew, Jeremy Stephen Lum, Jeremy Stephen Lum, Nicholas John Geraghty, Nicholas John Geraghty, Justin John Yerbury, Justin John Yerbury, Neil R. Cashman
Published 2020-11-01

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

by Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman, Cheryl L. Wellington
Published 2020-03-01

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

by Wai Hang Cheng, Kris M. Martens, Asma Bashir, Honor Cheung, Sophie Stukas, Ebrima Gibbs, Dhananjay R. Namjoshi, Emily B. Button, Anna Wilkinson, Carlos J. Barron, Neil R. Cashman, Peter A. Cripton, Cheryl L. Wellington
Published 2019-01-01