Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin.

by Elizabeth Donohue, Aruna D Balgi, Masaaki Komatsu, Michel Roberge
Published 2014-01-01

Regulation of mTORC1 signaling by pH.

by Aruna D Balgi, Graham H Diering, Elizabeth Donohue, Karen K Y Lam, Bruno D Fonseca, Carla Zimmerman, Masayuki Numata, Michel Roberge
Published 2011-01-01

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

by Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge
Published 2009-09-01

Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

by Esther Gies, Inga Wilde, Jason M Winget, Maria Brack, Barak Rotblat, Carolina Arias Novoa, Aruna D Balgi, Poul H Sorensen, Michel Roberge, Thibault Mayor
Published 2010-12-01

Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

by Karen K Y Lam, Xingji Zheng, Roberto Forestieri, Aruna D Balgi, Matt Nodwell, Sarah Vollett, Hilary J Anderson, Raymond J Andersen, Yossef Av-Gay, Michel Roberge
Published 2012-01-01

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

by Aruna D Balgi, Jun Wang, Daphne Y H Cheng, Chunlong Ma, Tom A Pfeifer, Yoko Shimizu, Hilary J Anderson, Lawrence H Pinto, Robert A Lamb, William F DeGrado, Michel Roberge
Published 2013-01-01

Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus

by Maggie C. Duncan, Pascal Amoa Onguéné, Ibuki Kihara, Derrick N. Nebangwa, Maya E. Naidu, David E. Williams, Aruna D. Balgi, Kerstin Andrae-Marobela, Michel Roberge, Raymond J. Andersen, Masahiro Niikura, Fidele Ntie-Kang, Ian Tietjen
Published 2020-06-01

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

by Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Published 2020-03-01