Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

by Craig A Glastonbury, Sara L Pulit, Julius Honecker, Jenny C Censin, Samantha Laber, Hanieh Yaghootkar, Nilufer Rahmioglu, Emilie Pastel, Katerina Kos, Andrew Pitt, Michelle Hudson, Christoffer Nellåker, Nicola L Beer, Hans Hauner, Christian M Becker, Krina T Zondervan, Timothy M Frayling, Melina Claussnitzer, Cecilia M Lindgren
Published 2020-08-01

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

by Luke C Pilling, Janice L Atkins, Michael O Duff, Robin N Beaumont, Samuel E Jones, Jessica Tyrrell, Chia-Ling Kuo, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Anna Murray, Michael N Weedon, Lorna W Harries, George A Kuchel, Luigi Ferrucci, Timothy M Frayling, David Melzer
Published 2017-01-01

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

by Timothy M. Frayling, Robin N. Beaumont, Samuel E. Jones, Hanieh Yaghootkar, Marcus A. Tuke, Katherine S. Ruth, Francesco Casanova, Ben West, Jonathan Locke, Seth Sharp, Yingjie Ji, William Thompson, Jamie Harrison, Amy S. Etheridge, Paul J. Gallins, Dereje Jima, Fred Wright, Yihui Zhou, Federico Innocenti, Cecilia M. Lindgren, Niels Grarup, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Jessica Tyrrell, Andrew R. Wood
Published 2018-04-01

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

by Samuel E Jones, Jessica Tyrrell, Andrew R Wood, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F Wilson, Fabiola Del Greco, Andrew A Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M Byrne, Philip R Gehrman, Henning Tiemeier, Karla V Allebrandt, Rachel M Freathy, Anna Murray, David A Hinds, Timothy M Frayling, Michael N Weedon
Published 2016-08-01

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

by Samuel E. Jones, Vincent T. van Hees, Diego R. Mazzotti, Pedro Marques-Vidal, Séverine Sabia, Ashley van der Spek, Hassan S. Dashti, Jorgen Engmann, Desana Kocevska, Jessica Tyrrell, Robin N. Beaumont, Melvyn Hillsdon, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Seth A. Sharp, Yingjie Ji, Jamie W. Harrison, Rachel M. Freathy, Anna Murray, Annemarie I. Luik, Najaf Amin, Jacqueline M. Lane, Richa Saxena, Martin K. Rutter, Henning Tiemeier, Zoltán Kutalik, Meena Kumari, Timothy M. Frayling, Michael N. Weedon, Philip R. Gehrman, Andrew R. Wood
Published 2019-04-01

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

by Samuel E. Jones, Jacqueline M. Lane, Andrew R. Wood, Vincent T. van Hees, Jessica Tyrrell, Robin N. Beaumont, Aaron R. Jeffries, Hassan S. Dashti, Melvyn Hillsdon, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Seth A. Sharp, Yingjie Jie, William D. Thompson, Jamie W. Harrison, Amy Dawes, Enda M. Byrne, Henning Tiemeier, Karla V. Allebrandt, Jack Bowden, David W. Ray, Rachel M. Freathy, Anna Murray, Diego R. Mazzotti, Philip R. Gehrman, Debbie A. Lawlor, Timothy M. Frayling, Martin K. Rutter, David A. Hinds, Richa Saxena, Michael N. Weedon
Published 2019-01-01

Cell Specific eQTL Analysis without Sorting Cells.

by Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R Wood, David Melzer, Luigi Ferrucci, Andrew B Singleton, Dena G Hernandez, Julian C Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H van den Berg, Jan H Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B J van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C Jansen, Lude Franke
Published 2015-05-01

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

by Vesna Boraska, Aaron Day-Williams, Christopher S Franklin, Katherine S Elliott, Kalliope Panoutsopoulou, Ioanna Tachmazidou, Eva Albrecht, Stefania Bandinelli, Lawrence J Beilin, Murielle Bochud, Gemma Cadby, Florian Ernst, David M Evans, Caroline Hayward, Andrew A Hicks, Jennifer Huffman, Cornelia Huth, Alan L James, Norman Klopp, Ivana Kolcic, Zoltán Kutalik, Debbie A Lawlor, Arthur W Musk, Marina Pehlic, Craig E Pennell, John R B Perry, Annette Peters, Ozren Polasek, Beate St Pourcain, Susan M Ring, Erika Salvi, Sabine Schipf, Jan A Staessen, Alexander Teumer, Nicholas Timpson, Veronique Vitart, Nicole M Warrington, Hanieh Yaghootkar, Tatijana Zemunik, Lina Zgaga, Ping An, Verneri Anttila, Ingrid B Borecki, Jostein Holmen, Ioanna Ntalla, Aarno Palotie, Kirsi H Pietiläinen, Juho Wedenoja, Bendik S Winsvold, George V Dedoussis, Jaakko Kaprio, Michael A Province, John-Anker Zwart, Michel Burnier, Harry Campbell, Daniele Cusi, George Davey Smith, Timothy M Frayling, Christian Gieger, Lyle J Palmer, Peter P Pramstaller, Igor Rudan, Henry Völzke, H-Erich Wichmann, Alan F Wright, Eleftheria Zeggini
Published 2012-01-01

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

by Aurélien Macé, Marcus A. Tuke, Patrick Deelen, Kati Kristiansson, Hannele Mattsson, Margit Nõukas, Yadav Sapkota, Ursula Schick, Eleonora Porcu, Sina Rüeger, Aaron F. McDaid, David Porteous, Thomas W. Winkler, Erika Salvi, Nick Shrine, Xueping Liu, Wei Q. Ang, Weihua Zhang, Mary F. Feitosa, Cristina Venturini, Peter J. van der Most, Anders Rosengren, Andrew R. Wood, Robin N. Beaumont, Samuel E. Jones, Katherine S. Ruth, Hanieh Yaghootkar, Jessica Tyrrell, Aki S. Havulinna, Harmen Boers, Reedik Mägi, Jennifer Kriebel, Martina Müller-Nurasyid, Markus Perola, Markku Nieminen, Marja-Liisa Lokki, Mika Kähönen, Jorma S. Viikari, Frank Geller, Jari Lahti, Aarno Palotie, Päivikki Koponen, Annamari Lundqvist, Harri Rissanen, Erwin P. Bottinger, Saima Afaq, Mary K. Wojczynski, Petra Lenzini, Ilja M. Nolte, Thomas Sparsø, Nicole Schupf, Kaare Christensen, Thomas T. Perls, Anne B. Newman, Thomas Werge, Harold Snieder, Timothy D. Spector, John C. Chambers, Seppo Koskinen, Mads Melbye, Olli T. Raitakari, Terho Lehtimäki, Martin D. Tobin, Louise V. Wain, Juha Sinisalo, Annette Peters, Thomas Meitinger, Nicholas G. Martin, Naomi R. Wray, Grant W. Montgomery, Sarah E. Medland, Morris A. Swertz, Erkki Vartiainen, Katja Borodulin, Satu Männistö, Anna Murray, Murielle Bochud, Sébastien Jacquemont, Fernando Rivadeneira, Thomas F. Hansen, Albertine J. Oldehinkel, Massimo Mangino, Michael A. Province, Panos Deloukas, Jaspal S. Kooner, Rachel M. Freathy, Craig Pennell, Bjarke Feenstra, David P. Strachan, Guillaume Lettre, Joel Hirschhorn, Daniele Cusi, Iris M. Heid, Caroline Hayward, Katrin Männik, Jacques S. Beckmann, Ruth J. F. Loos, Dale R. Nyholt, Andres Metspalu, Johan G. Eriksson, Michael N. Weedon, Veikko Salomaa, Lude Franke, Alexandre Reymond, Timothy M. Frayling, Zoltán Kutalik
Published 2017-09-01