Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth

by Olga N. Karpus, B. Florien Westendorp, Jacqueline L.M. Vermeulen, Sander Meisner, Jan Koster, Vanesa Muncan, Manon E. Wildenberg, Gijs R. van den Brink
Published 2019-03-01

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy

by Mattheus C.B. Wielenga, Selcuk Colak, Jarom Heijmans, Jooske F. van Lidth de Jeude, Hans M. Rodermond, James C. Paton, Adrienne W. Paton, Louis Vermeulen, Jan Paul Medema, Gijs R. van den Brink
Published 2015-10-01

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial RegenerationSummary

by Paula S. Montenegro-Miranda, Jonathan H.M. van der Meer, Christine Jones, Sander Meisner, Jacqueline L.M. Vermeulen, Jan Koster, Manon E. Wildenberg, Jarom Heijmans, Francois Boudreau, Agnes Ribeiro, Gijs R. van den Brink, Vanesa Muncan
Published 2020-01-01

Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease.

by Jessica R de Bruyn, Marte A Becker, Jessica Steenkamer, Manon E Wildenberg, Sybren L Meijer, Christianne J Buskens, Willem A Bemelman, Mark Löwenberg, Cyriel Y Ponsioen, Gijs R van den Brink, Geert R D'Haens
Published 2018-01-01

Correction: Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models.

by Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Izak Biemond, Antwan G Ederveen, Patrick G Groothuis, Sietse Mosselman, James C Hardwick, Daniel W Hommes, Gijs R van den Brink
Published 2013-01-01

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.

by Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Izak Biemond, Antwan G Ederveen, Patrick G Groothuis, Sietse Mosselman, James C Hardwick, Daniel W Hommes, Gijs R van den Brink
Published 2011-01-01

Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

by Marco Gerling, Nikè V.J.A. Büller, Leonard M Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergström, Raoul V. Kuiper, Leander Blaas, Mattheus C. B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund, Gijs R. van den Brink, Rune Toftgård
Published 2016-09-01

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

by Marco Gerling, Nikè V. J. A. Büller, Leonard M. Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergström, Raoul V. Kuiper, Leander Blaas, Mattheus C. B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund, Gijs R. van den Brink, Rune Toftgård
Published 2016-08-01

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

by Bartolomeus J. Meijer, Wouter L. Smit, Pim J. Koelink, Barbara F. Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L. M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin, Evelien Dekker, Vanesa Muncan, Gijs R. van den Brink, Jarom Heijmans
Published 2021-05-01

ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial RepairSummary

by Bartolomeus J. Meijer, Francesca P. Giugliano, Bart Baan, Jonathan H.M. van der Meer, Sander Meisner, Manon van Roest, Pim J. Koelink, Ruben J. de Boer, Nic Jones, Wolfgang Breitwieser, Nicole N. van der Wel, Manon E. Wildenberg, Gijs R. van den Brink, Jarom Heijmans, Vanesa Muncan
Published 2020-01-01

Indian Hedgehog Suppresses a Stromal Cell–Driven Intestinal Immune Response

by B. Florien Westendorp, Nikè V.J.A. Büller, Olga N. Karpus, Willemijn A. van Dop, Jan Koster, Rogier Versteeg, Pim J. Koelink, Clinton Y. Snel, Sander Meisner, Joris J.T.H. Roelofs, Anja Uhmann, Emiel Ver Loren van Themaat, Jarom Heijmans, Heidi Hahn, Vanesa Muncan, Manon E. Wildenberg, Gijs R. van den Brink
Published 2018-01-01

FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

by Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A. van Burgsteden, Elsa C. Kuijper, Christianne J. Buskens, Willem A. Bemelman, Sebastiaan A. J. Zaat, Reuven Agami, Gestur Vidarsson, Gijs R. van den Brink, Esther C. de Jong, Manon E. Wildenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Published 2018-02-01

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

by Jarom Heijmans, Jooske F. van Lidth de Jeude, Bon-Kyoung Koo, Sanne L. Rosekrans, Mattheus C.B. Wielenga, Marc van de Wetering, Marc Ferrante, Amy S. Lee, Jos J.M. Onderwater, James C. Paton, Adrienne W. Paton, A. Mieke Mommaas, Liudmila L. Kodach, James C. Hardwick, Daniël W. Hommes, Hans Clevers, Vanesa Muncan, Gijs R. van den Brink
Published 2013-04-01

Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

by Jonathan H. M. van der Meer, Ruben J. de Boer, Bartolomeus J. Meijer, Wouter L. Smit, Jacqueline L. M. Vermeulen, Sander Meisner, Manon van Roest, Pim J. Koelink, Evelien Dekker, Theodorus B. M. Hakvoort, Jan Koster, Lukas J. A. C. Hawinkels, Jarom Heijmans, Eduard A. Struijs, Marja A. Boermeester, Gijs R. van den Brink, Vanesa Muncan
Published 2021-10-01