MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei.

by W Joost Wiersinga, Catharina W Wieland, Joris J T H Roelofs, Tom van der Poll
Published 2008-01-01

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation

by JanWillem Duitman, Leonie Hartl, Joris J. T. H. Roelofs, Maarten F. Bijlsma, C. Arnold Spek
Published 2021-07-01

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

by Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans
Published 2020-12-01

Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection.

by Lionel Lattenist, Jesper Kers, Nike Claessen, Ineke J M ten Berge, Frederike J Bemelman, Sandrine Florquin, Joris J T H Roelofs
Published 2013-01-01

Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia

by Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz, W. Joost Wiersinga
Published 2020-08-01

Optical coherence tomography for identification and quantification of human airway wall layers.

by Julia N S d'Hooghe, Annika W M Goorsenberg, Daniel M de Bruin, Joris J T H Roelofs, Jouke T Annema, Peter I Bonta
Published 2017-01-01

Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice

by Esther K. Wolthuis, Alexander P. J. Vlaar, Goda Choi, Joris J. T. H. Roelofs, Marcel Levi, Nicole P. Juffermans, Marcus J. Schultz
Published 2012-01-01

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

by Liesbeth M Kager, W Joost Wiersinga, Joris J T H Roelofs, Onno J de Boer, Hartmut Weiler, Cornelis van 't Veer, Tom van der Poll
Published 2014-04-01

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS

by Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz, Wim K. Lagrand
Published 2019-07-01

Intestinal colonization with Enterococcus faecium does not influence pulmonary defense against Pseudomonas aeruginosa in mice.

by Masja Leendertse, Rob J L Willems, Ida A J Giebelen, Joris J T H Roelofs, Janetta Top, Marc J M Bonten, Tom van der Poll
Published 2009-08-01

Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia.

by Sacha F de Stoppelaar, Hester J Bootsma, Aldert Zomer, Joris J T H Roelofs, Peter W M Hermans, Cornelis van 't Veer, Tom van der Poll
Published 2013-01-01

Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury

by Esther K. Wolthuis, Alexander P. J. Vlaar, Jorrit-Jan H. Hofstra, Joris J. T. H. Roelofs, Vivian de Waard, Nicole P. Juffermans, Marcus J. Schultz
Published 2011-01-01

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.

by Wanhai Qin, Xanthe Brands, Cornelis Van't Veer, Alex F de Vos, Jean-Claude Sirard, Joris J T H Roelofs, Brendon P Scicluna, Tom van der Poll
Published 2021-04-01

NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin.

by Angelique M L Scantlebery, Melissa Uil, Loes M Butter, Renée Poelman, Nike Claessen, Stephen E Girardin, Sandrine Florquin, Joris J T H Roelofs, Jaklien C Leemans
Published 2019-01-01

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia.

by Florry E van den Boogaard, Jorrit J Hofstra, Cornelis van 't Veer, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll, Marcus J Schultz
Published 2015-01-01

Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model

by Jack Yang, Ivan Ramirez Moral, Cornelis van ’t Veer, Alex F. de Vos, Regina de Beer, Joris J. T. H. Roelofs, B. Paul Morgan, Tom van der Poll
Published 2019-07-01

Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the ‘resistant’ C57Bl/6J mouse strain

by Melissa Uil, Angelique M. L. Scantlebery, Loes M. Butter, Per W. B. Larsen, Onno J. de Boer, Jaklien C. Leemans, Sandrine Florquin, Joris J. T. H. Roelofs
Published 2018-04-01

Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis

by Natasja A. Otto, Liza Pereverzeva, Valentine Leopold, Ivan Ramirez-Moral, Joris J. T. H. Roelofs, Jeroen W. J. van Heijst, Alex F. de Vos, Tom van der Poll
Published 2021-01-01

Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

by Hendrik J. F. Helmerhorst, Laura R. A. Schouten, Gerry T. M. Wagenaar, Nicole P. Juffermans, Joris J. T. H. Roelofs, Marcus J. Schultz, Evert de Jonge, David J. van Westerloo
Published 2017-05-01

Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

by Derek J. B. Kleinveld, Mathijs R. Wirtz, Daan P. van den Brink, M. Adrie W. Maas, Joris J. T. H. Roelofs, J. Carel Goslings, Markus W. Hollmann, Nicole P. Juffermans
Published 2019-07-01