Esterase mutation is a mechanism of resistance to antimalarial compounds

by Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg
Published 2017-01-01

Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface

by Matthias Garten, Josh R. Beck, Robyn Roth, Tatyana Tenkova-Heuser, John Heuser, Eva S. Istvan, Christopher K. E. Bleck, Daniel E. Goldberg, Joshua Zimmerberg
Published 2020-07-01

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

by Eva S Istvan, Sudipta Das, Suyash Bhatnagar, Josh R Beck, Edward Owen, Manuel Llinas, Suresh M Ganesan, Jacquin C Niles, Elizabeth Winzeler, Akhil B Vaidya, Daniel E Goldberg
Published 2019-03-01

A broad analysis of resistance development in the malaria parasite

by Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou, Paul A. Willis, Francisco-Javier Gamo, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
Published 2016-06-01

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

by Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Published 2021-01-01