TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer

by Zhouhong Ge, Maikel P. Peppelenbosch, Dave Sprengers, Jaap Kwekkeboom
Published 2021-07-01

Cancer Cell B7-H3 Expression Is More Prevalent in the Pancreato-Biliary Subtype of Ampullary Cancer Than in Pancreatic Cancer

by Emma E. Geerdes, Kostandinos Sideras, Kostandinos Sideras, M. Hosein Aziz, Casper H. van Eijck, Marco J. Bruno, Dave Sprengers, Patrick P. C. Boor, Jaap Kwekkeboom
Published 2021-04-01

Detection of oncogenic mutations in paired circulating tumor DNA and circulating tumor cells in patients with hepatocellular carcinoma

by Zhouhong Ge, Jean C.A. Helmijr, Maurice P.H.M. Jansen, Patrick P.C. Boor, Lisanne Noordam, Maikel Peppelenbosch, Jaap Kwekkeboom, Jaco Kraan, Dave Sprengers
Published 2021-07-01

Combining Sorafenib and Immunosuppression in Liver Transplant Recipients with Hepatocellular Carcinoma

by Koen G. A. M. Hussaarts, Leni van Doorn, Sander Bins, Dave Sprengers, Peter de Bruijn, Roelof W. F. van Leeuwen, Stijn L. W. Koolen, Teun van Gelder, Ron H. J. Mathijssen
Published 2021-01-01

Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma

by Lisanne Noordam, Zhouhong Ge, Hadiye Özturk, Michail Doukas, Shanta Mancham, Patrick P. C. Boor, Lucia Campos Carrascosa, Guoying Zhou, Thierry P. P. van den Bosch, Qiuwei Pan, Jan N. M. IJzermans, Marco J. Bruno, Dave Sprengers, Jaap Kwekkeboom
Published 2021-05-01

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

by Meng Li, Ling Wang, Yijin Wang, Shaoshi Zhang, Guoying Zhou, Ruby Lieshout, Buyun Ma, Jiaye Liu, Changbo Qu, Monique M. A. Verstegen, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Wanlu Cao, Maikel P. Peppelenbosch, Qiuwei Pan
Published 2020-01-01

TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8+ T Cells in Hepatocellular CarcinomaSummary

by Zhouhong Ge, Guoying Zhou, Lucia Campos Carrascosa, Erik Gausvik, Patrick P.C. Boor, Lisanne Noordam, Michael Doukas, Wojciech G. Polak, Türkan Terkivatan, Qiuwei Pan, R. Bart Takkenberg, Joanne Verheij, Joris I. Erdmann, Jan N.M. IJzermans, Maikel P. Peppelenbosch, Jaco Kraan, Jaap Kwekkeboom, Dave Sprengers
Published 2021-01-01

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

by Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno
Published 2018-07-01

FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells

by Lucia Campos Carrascosa, Adriaan A van Beek, Valeska de Ruiter, Michail Doukas, Timothy S Fisher, Keith Ching, Karlijn van Loon, Patrick P C Boor, Yannick S Rakké, Lisanne Noordam, Pascal Doornebosch, Dirk Grünhagen, Kees Verhoef, Wojciech G Polak, Jan N M IJzermans, Irene Ni, Yik Andy Yeung, Dave Sprengers, Jaap Kwekkeboom
Published 2020-07-01

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

by Wanlu Cao, Meng Li, Jiaye Liu, Shaoshi Zhang, Lisanne Noordam, Monique M. A. Verstegen, Ling Wang, Buyun Ma, Shan Li, Wenshi Wang, Michiel Bolkestein, Michael Doukas, Kan Chen, Zhongren Ma, Marco Bruno, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
Published 2020-04-01

Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study

by Rogier Baak, François E. J. A. Willemssen, Yvette van Norden, Ferry A. L. M. Eskens, Maaike T. W. Milder, Ben J. M. Heijmen, Bas Groot Koerkamp, Dave Sprengers, Lydi M. J. W. van Driel, Heinz-Josef Klümpen, Wilhelm den Toom, Merel S. Koedijk, Jan N. M. IJzermans, Alejandra Méndez Romero
Published 2021-08-01

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

by Kostandinos Sideras, Katharina Biermann, Joanne Verheij, Bart R. Takkenberg, Shanta Mancham, Bettina E. Hansen, Hannah M. Schutz, Robert A. de Man, Dave Sprengers, Sonja I. Buschow, Maddy C. M. Verseput, Patrick P. C. Boor, Qiuwei Pan, Thomas M. van Gulik, Turkan Terkivatan, Jan N. M. Ijzermans, Ulrich H. W. Beuers, Stefan Sleijfer, Marco J. Bruno, Jaap Kwekkeboom
Published 2017-02-01