Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

by Ruben A. G. van Eerden, Esther Oomen-de Hoop, Aad Noordam, Ron H. J. Mathijssen, Stijn L. W. Koolen
Published 2021-02-01

Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

by Lena Klopp-Schulze, Anna Mueller-Schoell, Anna Mueller-Schoell, Patrick Neven, Stijn L. W. Koolen, Ron H. J. Mathijssen, Markus Joerger, Charlotte Kloft
Published 2020-03-01

Development of [²²⁵Ac]Ac-PSMA-I&T for Targeted Alpha Therapy According to GMP Guidelines for Treatment of mCRPC

by Eline L. Hooijman, Yozlem Chalashkan, Sui Wai Ling, Figen F. Kahyargil, Marcel Segbers, Frank Bruchertseifer, Alfred Morgenstern, Yann Seimbille, Stijn L. W. Koolen, Tessa Brabander, Erik de Blois
Published 2021-05-01

The Influence of Body Composition on the Systemic Exposure of Paclitaxel in Esophageal Cancer Patients

by Leni van Doorn, Marie-Rose B. S. Crombag, Hánah N. Rier, Jeroen L. A. van Vugt, Charlotte van Kesteren, Sander Bins, Ron H. J. Mathijssen, Mark-David Levin, Stijn L. W. Koolen
Published 2021-01-01

Combining Sorafenib and Immunosuppression in Liver Transplant Recipients with Hepatocellular Carcinoma

by Koen G. A. M. Hussaarts, Leni van Doorn, Sander Bins, Dave Sprengers, Peter de Bruijn, Roelof W. F. van Leeuwen, Stijn L. W. Koolen, Teun van Gelder, Ron H. J. Mathijssen
Published 2021-01-01

Population Pharmacokinetics of Oxycodone and Metabolites in Patients with Cancer-Related Pain

by Bram C. Agema, Astrid W. Oosten, Sebastiaan D.T. Sassen, Wim J.R. Rietdijk, Carin C.D. van der Rijt, Birgit C.P. Koch, Ron H.J. Mathijssen, Stijn L.W. Koolen
Published 2021-06-01

Effects of smoking and body mass index on the exposure of fentanyl in patients with cancer.

by Evelien J M Kuip, Wendy H Oldenmenger, Martine F Thijs-Visser, Peter de Bruijn, Astrid W Oosten, Esther Oomen-de Hoop, Stijn L W Koolen, Carin C D Van der Rijt, Ron H J Mathijssen
Published 2018-01-01

Influence of Genetic Variation in <i>COMT</i> on Cisplatin-Induced Nephrotoxicity in Cancer Patients

by Bram C. Agema, Stijn L.W. Koolen, Mirjam de With, Nadia van Doorn, Niels Heersche, Esther Oomen-de Hoop, Sabine Visser, Joachim G.J.V. Aerts, Sander Bins, Ron H.N. van Schaik, Ron H.J. Mathijssen
Published 2020-03-01

Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer

by Sander Bins, Stijn L. W. Koolen, Astrid A. M. van der Veldt, Stefan Sleijfer, Ron H. J. Mathijssen, Joachim G. J. V. Aerts, Ron H. N. van Schaik, Nina Schepers, Esther Oomen-De Hoop, Samira El Bouazzaoui
Published 2020-06-01

Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634

by Florence Atrafi, Ruben A. G. van Eerden, Stijn L. W. Koolen, Peter de Bruijn, Cristianne J. F. Rijcken, Rob Hanssen, Ferry A. L. M. Eskens, Martijn P. Lolkema, Esther Oomen-de Hoop, Jeffrey Damman, Ron H. J. Mathijssen
Published 2021-07-01

Pharmacokinetics of Sublingually Delivered Fentanyl in Head and Neck Cancer Patients Treated with Curatively Aimed Chemo or Bioradiotherapy

by Evelien J. M. Kuip, Wendy H. Oldenmenger, Esther Oomen-de Hoop, Gerda M. Verduijn, Martine F. Thijs-Visser, Peter de Bruijn, Esther van Meerten, Stijn L. W. Koolen, Ron H. J. Mathijssen, Carin C. D. van der Rijt
Published 2018-11-01

Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio

by Clara Inkyung Lee, Siew Kee Low, Ricardo Maldonado, Peter Fox, Bavanthi Balakrishnar, Sally Coulter, Peter de Bruijn, Stijn L.W. Koolen, Bo Gao, Jodi Lynch, Nicholas Zdenkowski, Rina Hui, Christopher Liddle, Ron H.J. Mathijssen, Nicholas Wilcken, Mark Wong, Howard Gurney
Published 2020-12-01

Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel

by Leni van Doorn, Mandy M. van Rosmalen, Wendy M. van der Deure, Esther Oomen-de Hoop, Robert Porrazzo, Sophie M. Wijngaard, Ingrid A. Boere, Paola Veenstra, Eman Ibrahim, Peter de Bruijn, Lena E. Friberg, Stijn L. W. Koolen, Ron H. J. Mathijssen, Agnes Jager
Published 2021-08-01

CD45RA+CCR7− CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab

by Andre Kunert, Edwin A. Basak, Daan P. Hurkmans, Hayri E. Balcioglu, Yarne Klaver, Mandy van Brakel, Astrid A. M. Oostvogels, Cor H. J. Lamers, Sander Bins, Stijn L. W. Koolen, Astrid A. M. van der Veldt, Stefan Sleijfer, Ron H. J. Mathijssen, Joachim G. J. V. Aerts, Reno Debets
Published 2019-06-01

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

by Koen G. A. M. Hussaarts, Leni van Doorn, Karel Eechoute, Jeffrey Damman, Qiang Fu, Nadia van Doorn, Eric D. Eisenmann, Alice A. Gibson, Esther Oomen-de Hoop, Peter de Bruijn, Sharyn D. Baker, Stijn L. W. Koolen, Teun van Gelder, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen, Alex Sparreboom, Sander Bins
Published 2020-08-01

Prospective real-world study on the pharmacokinetics of pembrolizumab in patients with solid tumors

by Markus Joerger, Reno Debets, Edwin A. Basak, Daan P. Hurkmans, Cor H. van der Leest, Sebastiaan D.T. Sassen, Karlijn de Joode, Lisanne Putter, Annemarie J.M. Wijkhuijs, Birgit C.P. Koch, Marco W.J. Schreurs, Astrid A.M. van der Veldt, Joachim G.J.V. Aerts, Ron H.J. Mathijssen, Stijn L.W. Koolen
Published 2021-06-01

A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients

by Daan P. Hurkmans, Edwin A. Basak, Tanja van Dijk, Darlene Mercieca, Marco W. J. Schreurs, Annemarie J. M. Wijkhuijs, Sander Bins, Esther Oomen-de Hoop, Reno Debets, Markus Joerger, Arlette Odink, Astrid A. M. van der Veldt, Cor H. van der Leest, Joachim G. J. V. Aerts, Ron H. J. Mathijssen, Stijn L. W. Koolen
Published 2019-07-01

Plasma Predictive Features in Treating EGFR-Mutated Non-Small Cell Lung Cancer

by Christi M. J. Steendam, G. D. Marijn Veerman, Melinda A. Pruis, Peggy Atmodimedjo, Marthe S. Paats, Cor van der Leest, Jan H. von der Thüsen, David C. Y. Yick, Esther Oomen-de Hoop, Stijn L. W. Koolen, Winand N. M. Dinjens, Ron H. N. van Schaik, Ron H. J. Mathijssen, Joachim G. J. V. Aerts, Hendrikus Jan Dubbink, Anne-Marie C. Dingemans
Published 2020-10-01