From Junk to Function: LncRNAs in CNS Health and Disease

by Rafaela Policarpo, Rafaela Policarpo, Rafaela Policarpo, Annerieke Sierksma, Annerieke Sierksma, Bart De Strooper, Bart De Strooper, Bart De Strooper, Constantin d’Ydewalle
Published 2021-07-01

Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?

by Giovanna Lalli, Jonathan M Schott, John Hardy, Bart De Strooper
Published 2021-08-01

In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.

by Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais
Published 2016-01-01

Regulation of amyloid precursor protein processing by serotonin signaling.

by Anna A Pimenova, Amantha Thathiah, Bart De Strooper, Ina Tesseur
Published 2014-01-01

LRRK2 expression is enriched in the striosomal compartment of mouse striatum

by Wim Mandemakers, An Snellinx, Michael J. O'Neill, Bart de Strooper
Published 2012-12-01

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.

by Véronique Dorval, Wim Mandemakers, Francis Jolivette, Laetitia Coudert, Rachid Mazroui, Bart De Strooper, Sébastien S Hébert
Published 2014-01-01

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

by Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Bruno Bergmans, Aikaterini S. Papadopoulou, André Delacourte, Bart De Strooper
Published 2009-03-01

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

by Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Published 2020-10-01

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

by Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Strooper
Published 2014-06-01

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

by Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Published 2021-07-01

Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

by Sébastien S. Hébert, Lutgarde Serneels, Tim Dejaegere, Katrien Horré, Michal Dabrowski, Veerle Baert, Wim Annaert, Dieter Hartmann, Bart De Strooper
Published 2004-11-01

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

by Sara Calafate, Arjan Buist, Katarzyna Miskiewicz, Vinoy Vijayan, Guy Daneels, Bart de Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechars
Published 2015-05-01

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease

by Philip W. Brownjohn, James Smith, Erik Portelius, Lutgarde Serneels, Hlin Kvartsberg, Bart De Strooper, Kaj Blennow, Henrik Zetterberg, Frederick J. Livesey
Published 2017-04-01

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

by Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers
Published 2020-03-01

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.

by Zoltan Ferjentsik, Shinichi Hayashi, J Kim Dale, Yasumasa Bessho, An Herreman, Bart De Strooper, Gonzalo del Monte, Jose Luis de la Pompa, Miguel Maroto
Published 2009-09-01

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study

by Seon-Ah Chong, Iryna Benilova, Hamdy Shaban, Bart De Strooper, Herman Devijver, Dieder Moechars, Wolfgang Eberle, Carmen Bartic, Fred Van Leuven, Geert Callewaert
Published 2011-12-01

Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

by Isabel H Salas, Zsuzsanna Callaerts-Vegh, Amaia M Arranz, Francesc X Guix, Rudi D'Hooge, José A Esteban, Bart De Strooper, Carlos G Dotti
Published 2017-01-01

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

by Isabel H Salas, Zsuzsanna Callaerts-Vegh, Amaia M Arranz, Francesc X Guix, Rudi D'Hooge, José A Esteban, Bart De Strooper, Carlos G Dotti
Published 2017-01-01

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

by Isabel H Salas, Zsuzsanna Callaerts-Vegh, Amaia M Arranz, Francesc X Guix, Rudi D'Hooge, José A Esteban, Bart De Strooper, Carlos G Dotti
Published 2017-01-01

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

by Kengo Uemura, Christina M Lill, Xuejing Li, Jessica A Peters, Alexander Ivanov, Zhanyun Fan, Bart DeStrooper, Brian J Bacskai, Bradley T Hyman, Oksana Berezovska
Published 2009-11-01