Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy

by Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven
Published 2014-07-01

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases

by Clément Menuet, Peter Borghgraef, Nicolas Voituron, Christian Gestreau, Lies Gielis, Herman Devijver, Mathias Dutschmann, Fred Van Leuven, Gérard Hilaire
Published 2012-04-01

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.

by Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuven
Published 2013-01-01

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study

by Seon-Ah Chong, Iryna Benilova, Hamdy Shaban, Bart De Strooper, Herman Devijver, Dieder Moechars, Wolfgang Eberle, Carmen Bartic, Fred Van Leuven, Geert Callewaert
Published 2011-12-01

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.

by Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Sophie Croes, Annelies Termont, David Demedts, Peter Borghgraef, Herman Devijver, Robert K Filipkowski, Leszek Kaczmarek, Sebastian Kügler, Fred Van Leuven
Published 2009-10-01

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.

by Peter Borghgraef, Clément Menuet, Clara Theunis, Justin V Louis, Herman Devijver, Hervé Maurin, Caroline Smet-Nocca, Guy Lippens, Gerard Hilaire, Harrie Gijsen, Dieder Moechars, Fred Van Leuven
Published 2013-01-01

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.

by Hervé Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G Stewart, Fred Van Leuven
Published 2014-01-01

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.

by Clara Theunis, Natalia Crespo-Biel, Valérie Gafner, Maria Pihlgren, María Pilar López-Deber, Pedro Reis, David T Hickman, Oskar Adolfsson, Nathalie Chuard, Dorin Mlaki Ndao, Peter Borghgraef, Herman Devijver, Fred Van Leuven, Andrea Pfeifer, Andreas Muhs
Published 2013-01-01

GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylationResearch in context

by Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
Published 2019-01-01