Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

by Christy O.Y. Hung, Frederick J. Livesey
Published 2018-12-01

Grouping and classifying electrophysiologically-defined classes of neocortical neurons by single cell, whole-genome expression profiling

by Tatiana Subkhankulova, Kojiro Yano, Hugh Robinson, Frederick J Livesey
Published 2010-04-01

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

by Lewis D. Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J. Livesey
Published 2018-03-01

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

by Philip W. Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J. Livesey
Published 2018-04-01

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease

by Philip W. Brownjohn, James Smith, Erik Portelius, Lutgarde Serneels, Hlin Kvartsberg, Bart De Strooper, Kaj Blennow, Henrik Zetterberg, Frederick J. Livesey
Published 2017-04-01

Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.

by Therese Andersson, Sabhi Rahman, Stephen N Sansom, Jessica M Alsiö, Masahiro Kaneda, James Smith, Donal O'Carroll, Alexander Tarakhovsky, Frederick J Livesey
Published 2010-10-01

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

by Stephen N Sansom, Dean S Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L Rubenstein, Frederick J Livesey
Published 2009-06-01

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

by Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon
Published 2018-07-01

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

by Christy Hung, Eleanor Tuck, Victoria Stubbs, Sven J. van der Lee, Cora Aalfs, Resie van Spaendonk, Philip Scheltens, John Hardy, Henne Holstege, Frederick J. Livesey
Published 2021-06-01

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

by Steven Moore, Lewis D.B. Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B. Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J. Livesey
Published 2015-05-01

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

by Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, Madeline A. Lancaster, Frederick J. Livesey, Michael J. McConnell, Ronald D. McKay, Eric M. Morrow, Alysson R. Muotri, David M. Panchision, Lee L. Rubin, Akira Sawa, Frank Soldner, Hongjun Song, Lorenz Studer, Sally Temple, Flora M. Vaccarino, Jun Wu, Pierre Vanderhaeghen, Fred H. Gage, Rudolf Jaenisch
Published 2015-12-01

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

by Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Published 2018-10-01