Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

by Antero Salminen, Anu Kauppinen, Kai Kaarniranta
Published 2013-02-01

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

by Anu Kauppinen, Kai Kaarniranta, Kai Kaarniranta, Antero Salminen
Published 2020-03-01

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration

by Janusz Blasiak, Sylwester Glowacki, Anu Kauppinen, Kai Kaarniranta
Published 2013-01-01

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

by Antero Salminen, Juha M. T. Hyttinen, Anu Kauppinen, Kai Kaarniranta
Published 2012-01-01

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells

by Niina Bhattarai, Eveliina Korhonen, Yashavanthi Mysore, Kai Kaarniranta, Anu Kauppinen
Published 2021-06-01

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degen...

by Maria Hytti, Eveliina Korhonen, Heidi Hongisto, Kai Kaarniranta, Heli Skottman, Anu Kauppinen
Published 2021-06-01

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

by Niina Piippo, Eveliina Korhonen, Maria Hytti, Kati Kinnunen, Kai Kaarniranta, Anu  Kauppinen
Published 2018-08-01

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells

by Niina Bhattarai, Niina Piippo, Sofia Ranta-aho, Yashavanthi Mysore, Kai Kaarniranta, Anu Kauppinen
Published 2021-01-01

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

by Sofia Ranta-aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti, Anu Kauppinen
Published 2021-05-01

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

by Yashavanthi Mysore, Eva M. del Amo, Sirpa Loukovaara, Marja Hagström, Arto Urtti, Anu Kauppinen
Published 2021-01-01

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

by Niina Bhattarai, Eveliina Korhonen, Maija Toppila, Ali Koskela, Kai Kaarniranta, Yashavanthi Mysore, Anu Kauppinen
Published 2020-03-01

Author Correction: Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

by Yashavanthi Mysore, Eva M. del Amo, Sirpa Loukovaara, Marja Hagström, Arto Urtti, Anu Kauppinen
Published 2021-07-01

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

by Maria Hytti, Eveliina Korhonen, Juha M. T. Hyttinen, Heidi Roehrich, Kai Kaarniranta, Deborah A. Ferrington, Anu Kauppinen
Published 2019-01-01

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

by Niina Piippo, Eveliina Korhonen, Maria Hytti, Heli Skottman, Kati Kinnunen, Natasha Josifovska, Goran Petrovski, Kai Kaarniranta, Anu Kauppinen
Published 2018-04-01

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

by Nicoletta Marchesi, Natthakan Thongon, Alessia Pascale, Alessandro Provenzani, Ali Koskela, Eveliina Korhonen, Adrian Smedowski, Stefano Govoni, Anu Kauppinen, Kai Kaarniranta, Marialaura Amadio
Published 2018-01-01

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

by Mária Szatmári-Tóth, Tanja Ilmarinen, Alexandra Mikhailova, Heli Skottman, Anu Kauppinen, Kai Kaarniranta, Endre Kristóf, Lyubomyr Lytvynchuk, Zoltán Veréb, László Fésüs, Goran Petrovski
Published 2019-02-01

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like <i>NFE2L2/PGC-1α</i> <i>^-/-</i> Mouse Model Evoke Complement Component C5a Indepen...

by Iswariyaraja Sridevi Gurubaran, Hanna Heloterä, Stephen Marry, Ali Koskela, Juha M. T. Hyttinen, Jussi J. Paterno, Arto Urtti, Mei Chen, Heping Xu, Anu Kauppinen, Kai Kaarniranta
Published 2021-07-01

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the <i>NFE2L2</i>/<i>PGC-1α</i>^-/- Mouse Model

by Iswariyaraja Sridevi Gurubaran, Johanna Viiri, Ali Koskela, Juha M.T. Hyttinen, Jussi J. Paterno, Gréta Kis, Miklós Antal, Arto Urtti, Anu Kauppinen, Szabolcs Felszeghy, Kai Kaarniranta
Published 2020-03-01

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

by Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Published 2019-01-01