Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

by Tuomas Ryhänen, Johanna Viiri, Juha M. T. Hyttinen, Hannu Uusitalo, Antero Salminen, Kai Kaarniranta
Published 2011-01-01

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the <i>NFE2L2</i>/<i>PGC-1α</i>^-/- Mouse Model

by Iswariyaraja Sridevi Gurubaran, Johanna Viiri, Ali Koskela, Juha M.T. Hyttinen, Jussi J. Paterno, Gréta Kis, Miklós Antal, Arto Urtti, Anu Kauppinen, Szabolcs Felszeghy, Kai Kaarniranta
Published 2020-03-01

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of <i>NFE2L2/PGC-1α</i> Double Knock-Out Mice

by Janusz Blasiak, Ali Koskela, Elzbieta Pawlowska, Mikko Liukkonen, Johanna Ruuth, Elisa Toropainen, Juha M. T. Hyttinen, Johanna Viiri, John E. Eriksson, Heping Xu, Mei Chen, Szabolcs Felszeghy, Kai Kaarniranta
Published 2021-02-01

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.

by Johanna Viiri, Marialaura Amadio, Nicoletta Marchesi, Juha M T Hyttinen, Niko Kivinen, Reijo Sironen, Kirsi Rilla, Saeed Akhtar, Alessandro Provenzani, Vito Giuseppe D'Agostino, Stefano Govoni, Alessia Pascale, Hansjurgen Agostini, Goran Petrovski, Antero Salminen, Kai Kaarniranta
Published 2013-01-01

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

by Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Published 2019-01-01