Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined Conditions

by Pyry Grönroos, Tanja Ilmarinen, Heli Skottman
Published 2021-02-01

Small-Molecule Induction Promotes Corneal Epithelial Cell Differentiation from Human Induced Pluripotent Stem Cells

by Alexandra Mikhailova, Tanja Ilmarinen, Hannu Uusitalo, Heli Skottman
Published 2014-02-01

Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method

by Heidi Hongisto, Tanja Ilmarinen, Meri Vattulainen, Alexandra Mikhailova, Heli Skottman
Published 2017-12-01

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degen...

by Maria Hytti, Eveliina Korhonen, Heidi Hongisto, Kai Kaarniranta, Heli Skottman, Anu Kauppinen
Published 2021-06-01

Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential

by Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto, Heli Skottman
Published 2019-08-01

The Effect of Human and Mouse Fibroblast Feeder Cells on Cardiac Differentiation of Human Pluripotent Stem Cells

by Mari Pekkanen-Mattila, Marisa Ojala, Erja Kerkelä, Kristiina Rajala, Heli Skottman, Katriina Aalto-Setälä
Published 2012-01-01

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery

by Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Published 2020-02-01

Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells.

by Iina Vainio, Amna Abu Khamidakh, Michelangelo Paci, Heli Skottman, Kati Juuti-Uusitalo, Jari Hyttinen, Soile Nymark
Published 2015-01-01

Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium.

by Loris Nanni, Michelangelo Paci, Florentino Luciano Caetano dos Santos, Heli Skottman, Kati Juuti-Uusitalo, Jari Hyttinen
Published 2016-01-01

Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.

by Kati Juuti-Uusitalo, Hanna Vaajasaari, Tuomas Ryhänen, Susanna Narkilahti, Riitta Suuronen, Eliisa Mannermaa, Kai Kaarniranta, Heli Skottman
Published 2012-01-01

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

by Niina Piippo, Eveliina Korhonen, Maria Hytti, Heli Skottman, Kati Kinnunen, Natasha Josifovska, Goran Petrovski, Kai Kaarniranta, Anu Kauppinen
Published 2018-04-01

Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage

by Amna E. Abu Khamidakh, Alejandra Rodriguez-Martinez, Kai Kaarniranta, Anne Kallioniemi, Heli Skottman, Jari Hyttinen, Kati Juuti-Uusitalo
Published 2018-07-01

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

by Mostafa Kiamehr, Alexa Klettner, Elisabeth Richert, Ali Koskela, Arto Koistinen, Heli Skottman, Kai Kaarniranta, Katriina Aalto-Setälä, Kati Juuti-Uusitalo
Published 2019-08-01

In Vitro Cultivation of Limbal Epithelial Stem Cells on Surface-Modified Crosslinked Collagen Scaffolds

by Michel Haagdorens, Vytautas Cėpla, Eline Melsbach, Laura Koivusalo, Heli Skottman, May Griffith, Ramūnas Valiokas, Nadia Zakaria, Isabel Pintelon, Marie-José Tassignon
Published 2019-01-01

Transcriptome profiling of human pre-implantation development.

by Pu Zhang, Marco Zucchelli, Sara Bruce, Fredwell Hambiliki, Anneli Stavreus-Evers, Lev Levkov, Heli Skottman, Erja Kerkelä, Juha Kere, Outi Hovatta
Published 2009-01-01

Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE

by Taina Viheriälä, Juhana Sorvari, Teemu O. Ihalainen, Anni Mörö, Pyry Grönroos, Sabrina Schlie-Wolter, Boris Chichkov, Heli Skottman, Soile Nymark, Tanja Ilmarinen
Published 2021-01-01

Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium

by Heidi Hongisto, Antti Jylhä, Janika Nättinen, Jochen Rieck, Tanja Ilmarinen, Zoltán Veréb, Ulla Aapola, Roger Beuerman, Goran Petrovski, Hannu Uusitalo, Heli Skottman
Published 2017-07-01

Healthy human CSF promotes glial differentiation of hESC-derived neural cells while retaining spontaneous activity in existing neuronal networks

by Heikki Kiiski, Riikka Äänismaa, Jyrki Tenhunen, Sanna Hagman, Laura Ylä-Outinen, Antti Aho, Arvi Yli-Hankala, Stepani Bendel, Heli Skottman, Susanna Narkilahti
Published 2013-05-01

Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium

by Julia K. Johansson, Viivi I. Karema-Jokinen, Satu Hakanen, Antti Jylhä, Hannu Uusitalo, Maija Vihinen-Ranta, Heli Skottman, Teemu O. Ihalainen, Soile Nymark
Published 2019-08-01

Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models

by Eva Ramsay, Manuela Raviña, Sanjay Sarkhel, Sarah Hehir, Neil R. Cameron, Tanja Ilmarinen, Heli Skottman, Jørgen Kjems, Arto Urtti, Marika Ruponen, Astrid Subrizi
Published 2020-07-01