Complement inhibition in severe COVID-19 – Blocking C5a seems to be key

by Endry H.T. Lim, Alexander P.J. Vlaar, Sanne de-Bruin, Matthijs C. Brouwer, Diederik van-de-Beek
Published 2021-05-01

Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice

by Esther K. Wolthuis, Alexander P. J. Vlaar, Goda Choi, Joris J. T. H. Roelofs, Marcel Levi, Nicole P. Juffermans, Marcus J. Schultz
Published 2012-01-01

Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study.

by Niels van Mourik, Hennie A Metske, Jorrit J Hofstra, Jan M Binnekade, Bart F Geerts, Marcus J Schultz, Alexander P J Vlaar
Published 2019-01-01

Correction: Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.

by Michel W J Smeets, Ruben Bierings, Henriet Meems, Frederik P J Mul, Dirk Geerts, Alexander P J Vlaar, Jan Voorberg, Peter L Hordijk
Published 2018-01-01

Prophylactic platelet transfusion prior to central venous catheter placement in patients with thrombocytopenia: study protocol for a randomised controlled trial

by Emma K. van de Weerdt, Bart J. Biemond, Sacha S. Zeerleder, Krijn P. van Lienden, Jan M. Binnekade, Alexander P. J. Vlaar, Study collaborative
Published 2018-02-01

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.

by Michel W J Smeets, Ruben Bierings, Henriet Meems, Frederik P J Mul, Dirk Geerts, Alexander P J Vlaar, Jan Voorberg, Peter L Hordijk
Published 2017-01-01

Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury

by Esther K. Wolthuis, Alexander P. J. Vlaar, Jorrit-Jan H. Hofstra, Joris J. T. H. Roelofs, Vivian de Waard, Nicole P. Juffermans, Marcus J. Schultz
Published 2011-01-01

Transfusion practice in the non-bleeding critically ill: an international online survey—the TRACE survey

by Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen, Alexander P. J. Vlaar, on behalf of the Cardiovascular Dynamics Section and Transfusion Guideline Task Force of the ESICM
Published 2019-09-01

Intramuscular adipose tissue at level Th12 is associated with survival in COVID‐19

by Alain R. Viddeleer, Joost Raaphorst, Minoesch Min, Ludo F.M. Beenen, Maeke J. Scheerder, Alexander P.J. Vlaar, Amsterdam UMC COVID‐19 Biobank, Martijn Beudel, Robert Hemke
Published 2021-06-01

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury.

by Jorrit J Hofstra, Alexander D Cornet, Paul J Declerck, Barry Dixon, Hamid Aslami, Alexander P J Vlaar, Joris J Roelofs, Tom van der Poll, Marcel Levi, Marcus J Schultz
Published 2013-01-01

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.

by Maria T Kuipers, Hamid Aslami, Alexander P J Vlaar, Nicole P Juffermans, Anita M Tuip-de Boer, Maria A Hegeman, Geartsje Jongsma, Joris J T H Roelofs, Tom van der Poll, Marcus J Schultz, Catharina W Wieland
Published 2012-01-01

High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.

by Maria T Kuipers, Thomas Vogl, Hamid Aslami, Geartsje Jongsma, Elske van den Berg, Alexander P J Vlaar, Joris J T H Roelofs, Nicole P Juffermans, Marcus J Schultz, Tom van der Poll, Johannes Roth, Catharina W Wieland
Published 2013-01-01

Cost-effectiveness in extracorporeal life support in critically ill adults in the Netherlands

by Annemieke Oude Lansink-Hartgring, Dinis Dos Reis Miranda, Dirk W. Donker, Jacinta J. Maas, Thijs Delnoij, Marijn Kuijpers, Judith van den Brule, Erik Scholten, Hendrik Endeman, Alexander P. J. Vlaar, Walter M. van den Bergh, On behalf of the Dutch ECLS study group
Published 2018-03-01

Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination

by Brent Appelman, Karlijn van der Straten, A.H. Ayesha Lavell, Michiel Schinkel, Marleen A. Slim, Meliawati Poniman, Judith A. Burger, Melissa Oomen, Khadija Tejjani, Alexander P.J. Vlaar, W. Joost Wiersinga, Yvo M. Smulders, Lonneke A. van Vught, Rogier W. Sanders, Marit J. van Gils, Marije K. Bomers, Jonne J. Sikkens
Published 2021-10-01

Y-RNA subtype ratios in plasma extracellular vesicles are cell type- specific and are candidate biomarkers for inflammatory diseases

by Tom A.P. Driedonks, Sanne Mol, Sanne de Bruin, Anna-Linda Peters, Xiaogang Zhang, Marthe F.S. Lindenbergh, Boukje M. Beuger, Anne-Marieke D. van Stalborch, Thom Spaan, Esther C. de Jong, Erhard van der Vries, Coert Margadant, Robin van Bruggen, Alexander P.J. Vlaar, Tom Groot Kormelink, Esther N.M. Nolte-‘T Hoen
Published 2020-01-01

Pre-PCI versus immediate post-PCI Impella initiation in acute myocardial infarction complicated by cardiogenic shock.

by Veemal V Hemradj, Mina Karami, Krischan D Sjauw, Annemarie E Engström, Dagmar M Ouweneel, Justin de Brabander, Marije M Vis, Joanna J Wykrzykowska, Marcel A Beijk, Karel T Koch, Jan Baan, Robbert J de Winter, Jan J Piek, Antoine H G Driessen, Wim K Lagrand, Alexander P J Vlaar, Jan Paul Ottervanger, José P S Henriques
Published 2020-01-01

RELAx – REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial

by Anna Geke Algera, Luigi Pisani, Dennis C. J. Bergmans, Sylvia den Boer, Corianne A. J. de Borgie, Frank H. Bosch, Karina Bruin, Thomas G. Cherpanath, Rogier M. Determann, Arjen M. Dondorp, Dave A. Dongelmans, Henrik Endeman, Jasper J. Haringman, Janneke Horn, Nicole P. Juffermans, David M. van Meenen, Nardo J. van der Meer, Maruschka P. Merkus, Hazra S. Moeniralam, Ilse Purmer, Pieter Roel Tuinman, Mathilde Slabbekoorn, Peter E. Spronk, Alexander P. J. Vlaar, Marcelo Gama de Abreu, Paolo Pelosi, Ary Serpa Neto, Marcus J. Schultz, Frederique Paulus, for the RELAx Investigators and the PROVE Network Investigators
Published 2018-05-01

Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation

by Eva M. Spoormans, Jorrit S. Lemkes, Gladys N. Janssens, Nina W. van der Hoeven, Lucia S.D. Jewbali, Eric A. Dubois, Peter M. van de Ven, Martijn Meuwissen, Tom A. Rijpstra, Hans A. Bosker, Michiel J. Blans, Gabe B. Bleeker, Remon Baak, Georgios J. Vlachojannis, Bob J.W. Eikemans, Pim van der Harst, Iwan C.C. van der Horst, Michiel Voskuil, Joris J. van der Heijden, Albertus Beishuizen, Martin Stoel, Cyril Camaro, Hans van der Hoeven, José P. Henriques, Alexander P.J. Vlaar, Maarten A. Vink, Bas van den Bogaard, Ton A.C.M. Heestermans, Wouter de Ruijter, Thijs S.R. Delnoij, Harry J.G.M. Crijns, Gillian A.J. Jessurun, Pranobe V. Oemrawsingh, Marcel T.M. Gosselink, Koos Plomp, Michael Magro, Paul W.G. Elbers, Yolande Appelman, Niels van Royen
Published 2020-12-01

Clinical features and prognostic factors in Covid-19: A prospective cohort study

by Sanne de Bruin, Lieuwe D. Bos, Marian A. van Roon, Anita M. Tuip-de Boer, Alex R. Schuurman, Marleen J.A. Koel-Simmelinck, Harm Jan Bogaard, Pieter Roel Tuinman, Michiel A. van Agtmael, Jörg Hamann, Charlotte E. Teunissen, W. Joost Wiersinga, A.H. (Koos) Zwinderman, Matthijs C. Brouwer, Diederik van de Beek, Alexander P.J. Vlaar, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Peter Bonta, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, David T.P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, David T.P. Buis, Maurits C.F.J. de Rotte, Mirjam Dijkstra, Dave A. Dongelmans, Romein W.G. Dujardin, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H.T. Lim, Niels van Mourik, Jeannine Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A.I. Piña-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Michiel Schinkel, Femke A.P. Schrauwen, Marcus J. Schultz, Alex Schuurmans, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, A.H (Koos) Zwinderman, Matthijs C. Brouwer, W. Joost Wiersinga, Alexander P.J. Vlaar
Published 2021-05-01

Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study

by Bernadette Schurink, PhD, Eva Roos, PhD, Teodora Radonic, PhD, Ellis Barbe, PhD, Catherine S C Bouman, PhD, Hans H de Boer, PhD, Godelieve J de Bree, PhD, Esther B Bulle, MD, Eleonora M Aronica, ProfPhD, Sandrine Florquin, ProfPhD, Judith Fronczek, PhD, Leo M A Heunks, ProfPhD, Menno D de Jong, ProfPhD, Lihui Guo, PhD, Romy du Long, MD, Rene Lutter, PhD, Pam C G Molenaar, BSc, E Andra Neefjes-Borst, MD, Hans W M Niessen, ProfPhD, Carel J M van Noesel, ProfPhD, Joris J T H Roelofs, PhD, Eric J Snijder, ProfPhD, Eline C Soer, PhD, Joanne Verheij, PhD, Alexander P J Vlaar, PhD, Wim Vos, MSc, Nicole N van der Wel, PhD, Allard C van der Wal, ProfPhD, Paul van der Valk, ProfPhD, Marianna Bugiani, PhD
Published 2020-11-01