Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre

by Michael Yan, Tzen S. Toh, Patricia E. Lindsay, Jessica Weiss, Katrina Hueniken, Christy Yeung, Vijithan Sugumar, Dixon Pinto, Tony Tadic, Alexander Sun, Andrea Bezjak, John Cho, Srinivas Raman, Meredith Giuliani, Fabio Ynoe Moraes, Geoffrey Liu, Andrew J. Hope, Benjamin H. Lok
Published 2021-09-01

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

by Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V. Bratman, Amit M. Oza, Suzanne Kamel-Reid, Suzanne Trudel, Trevor J. Pugh
Published 2017-05-01

Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

by Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Published 2019-09-01

Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

by Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Published 2019-06-01

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

by Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu
Published 2019-03-01

Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes

by Oliver A. Kent, Manipa Saha, Etienne Coyaud, Helen E. Burston, Napoleon Law, Keith Dadson, Sujun Chen, Estelle M. Laurent, Jonathan St-Germain, Ren X. Sun, Yoshinori Matsumoto, Justin Cowen, Aaryn Montgomery-Song, Kevin R. Brown, Charles Ishak, Jose La Rose, Daniel D. De Carvalho, Housheng Hansen He, Brian Raught, Filio Billia, Peter Kannu, Robert Rottapel
Published 2020-09-01

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

by Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien
Published 2020-01-01

CIC protein instability contributes to tumorigenesis in glioblastoma

by Severa Bunda, Pardeep Heir, Julie Metcalf, Annie Si Cong Li, Sameer Agnihotri, Stefan Pusch, Mamatjan Yasin, Mira Li, Kelly Burrell, Sheila Mansouri, Olivia Singh, Mark Wilson, Amir Alamsahebpour, Romina Nejad, Bethany Choi, David Kim, Andreas von Deimling, Gelareh Zadeh, Kenneth Aldape
Published 2019-02-01

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

by S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh
Published 2021-08-01

ONECUT2 is a driver of neuroendocrine prostate cancer

by Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He
Published 2019-01-01

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

by Sameer Agnihotri, Suganth Suppiah, Peter D. Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P. Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas von Deimling, Michael D. Taylor, Normand J. Laperriere, Trevor J. Pugh, Kenneth D. Aldape, Gelareh Zadeh
Published 2017-08-01

Orchestrating and sharing large multimodal data for transparent and reproducible research

by Anthony Mammoliti, Petr Smirnov, Minoru Nakano, Zhaleh Safikhani, Christopher Eeles, Heewon Seo, Sisira Kadambat Nair, Arvind S. Mer, Ian Smith, Chantal Ho, Gangesh Beri, Rebecca Kusko, Massive Analysis Quality Control (MAQC) Society Board of Directors, Eva Lin, Yihong Yu, Scott Martin, Marc Hafner, Benjamin Haibe-Kains
Published 2021-10-01

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

by Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains
Published 2021-02-01

Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro

by Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Published 2018-01-01

Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells

by Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John E. Dick, Eric R. Lechman
Published 2019-10-01

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

by Dharmendra Dingar, William B. Tu, Diana Resetca, Corey Lourenco, Aaliya Tamachi, Jason De Melo, Kathleen E. Houlahan, Manpreet Kalkat, Pak-Kei Chan, Paul C. Boutros, Brian Raught, Linda Z. Penn
Published 2018-08-01

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

by Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Published 2020-08-01

Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial

by Kathryn Ottolino-Perry, Anam Shahid, Stephanie DeLuca, Viktor Son, Mayleen Sukhram, Fannong Meng, Zhihui ( Amy) Liu, Sara Rapic, Nayana Thalanki Anantha, Shirley C. Wang, Emilie Chamma, Christopher Gibson, Philip J. Medeiros, Safa Majeed, Ashley Chu, Olivia Wignall, Alessandra Pizzolato, Cheryl F. Rosen, Liis Lindvere Teene, Danielle Starr-Dunham, Iris Kulbatski, Tony Panzarella, Susan J. Done, Alexandra M. Easson, Wey L. Leong, Ralph S. DaCosta
Published 2021-07-01

Gene isoforms as expression-based biomarkers predictive of drug response in vitro

by Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Published 2017-10-01

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

by Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran, Samah El Ghamrasni, Justin Jeon, Parasvi Patel, Mohamed Saad Eldin, Rob Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem, Razqallah Hakem
Published 2016-08-01