A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.

by Yulia Jitkova, Marcela Gronda, Rose Hurren, Xiaoming Wang, Carolyn A Goard, Bozhena Jhas, Aaron D Schimmer
Published 2014-01-01

Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment

by Aaron D. Schimmer, Rashim Pal Singh, Ayesh K. Seneviratne, Geethu E. Thomas, Neil MacLean, Rose Hurren
Published 2020-12-01

Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells.

by Bozhena Jhas, Shrivani Sriskanthadevan, Marko Skrtic, Mahadeo A Sukhai, Veronique Voisin, Yulia Jitkova, Marcela Gronda, Rose Hurren, Rob C Laister, Gary D Bader, Mark D Minden, Aaron D Schimmer
Published 2013-01-01

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

by Rida Mourtada, Sonali B Fonseca, Simon P Wisnovsky, Mark P Pereira, Xiaoming Wang, Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin A J Smith, Michael P Murphy, Aaron D Schimmer, Shana O Kelley
Published 2013-01-01

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

by Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Published 2021-03-01

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

by Gregory A. Reed, Gary J. Schiller, Suman Kambhampati, Martin S. Tallman, Dan Douer, Mark D. Minden, Karen W. Yee, Vikas Gupta, Joseph Brandwein, Yulia Jitkova, Marcela Gronda, Rose Hurren, Aisha Shamas‐Din, Andre C. Schuh, Aaron D. Schimmer
Published 2016-11-01

Suppression of cancer progression by MGAT1 shRNA knockdown.

by Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Published 2012-01-01

Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.

by G Wei Xu, Julia I Toth, Sara R da Silva, Stacey-Lynn Paiva, Julie L Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A Sukhai, Rabindra N Bhattacharjee, Carolyn A Goard, Bruno Medeiros, Patrick T Gunning, Sirano Dhe-Paganon, Matthew D Petroski, Aaron D Schimmer
Published 2014-01-01

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

by Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains
Published 2021-02-01