Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

by Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P. Jackson, Jörg Menche, Joanna I. Loizou
Published 2017-11-01

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

by Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Published 2020-12-01

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

by Leonhard X. Heinz, Christoph L. Baumann, Marielle S. Köberlin, Berend Snijder, Riem Gawish, Guanghou Shui, Omar Sharif, Irene M. Aspalter, André C. Müller, Richard K. Kandasamy, Florian P. Breitwieser, Andreas Pichlmair, Manuela Bruckner, Manuele Rebsamen, Stephan Blüml, Thomas Karonitsch, Astrid Fauster, Jacques Colinge, Keiryn L. Bennett, Sylvia Knapp, Markus R. Wenk, Giulio Superti-Furga
Published 2015-06-01

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

by Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou, Sebastian M. B. Nijman
Published 2016-12-01

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

by André F. Rendeiro, Thomas Krausgruber, Nikolaus Fortelny, Fangwen Zhao, Thomas Penz, Matthias Farlik, Linda C. Schuster, Amelie Nemc, Szabolcs Tasnády, Marienn Réti, Zoltán Mátrai, Donát Alpár, Csaba Bödör, Christian Schmidl, Christoph Bock
Published 2020-01-01

The VRNetzer platform enables interactive network analysis in Virtual Reality

by Sebastian Pirch, Felix Müller, Eugenia Iofinova, Julia Pazmandi, Christiane V. R. Hütter, Martin Chiettini, Celine Sin, Kaan Boztug, Iana Podkosova, Hannes Kaufmann, Jörg Menche
Published 2021-04-01

Mapping the perturbome network of cellular perturbations

by Michael Caldera, Felix Müller, Isabel Kaltenbrunner, Marco P. Licciardello, Charles-Hugues Lardeau, Stefan Kubicek, Jörg Menche
Published 2019-11-01

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

by Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W. Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M. Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P. Jackson, Joanna I. Loizou
Published 2018-06-01

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

by Anna Moskovskich, Ulrich Goldmann, Felix Kartnig, Sabrina Lindinger, Justyna Konecka, Giuseppe Fiume, Enrico Girardi, Giulio Superti-Furga
Published 2019-07-01

Enhancing cognate target elution efficiency in gel-free chemical proteomics

by Branka Radic-Sarikas, Uwe Rix, Alexey Stukalov, Manuela Gridling, André C. Müller, Jacques Colinge, Giulio Superti-Furga, Keiryn L. Bennett
Published 2015-12-01

High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells

by Ruochen Jia, Leon Kutzner, Anna Koren, Kathrin Runggatscher, Peter Májek, André C. Müller, Michael Schuster, Christoph Bock, Joanna I. Loizou, Stefan Kubicek, Robert Kralovics
Published 2021-07-01

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

by Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson
Published 2017-08-01

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus

by Mark Smyth, Kseniya Khamina, Alexandra Popa, Venugopal Gudipati, Benedikt Agerer, Alexander Lercher, Lindsay Kosack, Lukas Endler, Hatoon Baazim, Csilla Viczenczova, Johannes B. Huppa, Andreas Bergthaler
Published 2021-06-01

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN

by Abdelghani Mazouzi, Alexey Stukalov, André C. Müller, Doris Chen, Marc Wiedner, Jana Prochazkova, Shih-Chieh Chiang, Michael Schuster, Florian P. Breitwieser, Andreas Pichlmair, Sherif F. El-Khamisy, Christoph Bock, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou
Published 2016-04-01

A substrate‐based ontology for human solute carriers

by Eva Meixner, Ulrich Goldmann, Vitaly Sedlyarov, Stefania Scorzoni, Manuele Rebsamen, Enrico Girardi, Giulio Superti‐Furga
Published 2020-07-01

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

by Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Published 2018-05-01

Single-Cell DNA Methylome Sequencing and Bioinformatic Inference of Epigenomic Cell-State Dynamics

by Matthias Farlik, Nathan C. Sheffield, Angelo Nuzzo, Paul Datlinger, Andreas Schönegger, Johanna Klughammer, Christoph Bock
Published 2015-03-01

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

by Eleni M. Tomazou, Nathan C. Sheffield, Christian Schmidl, Michael Schuster, Andreas Schönegger, Paul Datlinger, Stefan Kubicek, Christoph Bock, Heinrich Kovar
Published 2015-02-01

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

by André F. Rendeiro, Christian Schmidl, Jonathan C. Strefford, Renata Walewska, Zadie Davis, Matthias Farlik, David Oscier, Christoph Bock
Published 2016-06-01