Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on alpha-Glucosidase Inhibitors and Their Molecular Docking

• Main Authors: Alshamrani, FJ (Author), Hayat, S (Author), Imran, S (Author), Khan, KM (Author), Naz, F (Author), Rahim, F (Author), Taha, M (Author), Ullah, H (Author), Zaman, K (Author)
• Format: Article
• Language: English
• Published: 2019
• Subjects: ACETYLCHOLINESTERASE; alpha-glucosidase; ANALOGS; BETA-GLUCURONIDASE; BIOLOGICAL EVALUATION; DERIVATIVES; IN-VITRO EVALUATION; molecular docking study; POTENTIAL INHIBITORS; QSAR; RHINOVIRUS; SAR; synthesis; thiosemicarbazide; THIOSEMICARBAZIDES; triazinoindole
• Online Access: View Fulltext in Publisher

 A new class of triazinoindole-bearing thiosemicarbazides (1-25) was synthesized and evaluated for alpha-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 +/- 0.01 to 35.80 +/- 0.80 mu M when compared to standard acarbose (an IC50 value of 38.60 +/- 0.20 mu M). Among the series, analogs 1 and 23 were found to be the most potent, with IC50 values of 1.30 +/- 0.05 and 1.30 +/- 0.01 mu M, respectively. The structure-activity relationship (SAR) was mainly based upon bringing about different substituents on the phenyl rings. To confirm the binding interactions, a molecular docking study was performed.