synthesis SAR chemistry 1,1-bis(3'-indolyl)methane 4-nitrophenyl ACETYLCHOLINESTERASE ANALOGS Alpha-glucosidase Anti-Bacterial Agents Antibacterial Antifungal Agents BETA-GLUCURONIDASE BIOLOGICAL EVALUATION Benzaldehydes Bisindole Schiff base Bisindolylmethane DERIVATIVES Glycoside Hydrolase Inhibitors Gram negative bacterium Gram positive bacterium Gram-Negative Bacteria Gram-Positive Bacteria Humans IN-VITRO EVALUATION Indole Indoles Molecular Docking Simulation Molecular docking study Nickel acetate Nitrophenols