Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on alpha-Glucosidase Inhibitors and Their Molecular Docking

Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on alpha-Glucosidase Inhibitors and Their Molecular Docking

A new class of triazinoindole-bearing thiosemicarbazides (1-25) was synthesized and evaluated for alpha-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 +/- 0.01 to 35.80 +/- 0.80 mu M when compared to standard aca...

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Bibliographic Details
Main Authors: Alshamrani, FJ (Author), Hayat, S (Author), Imran, S (Author), Khan, KM (Author), Naz, F (Author), Rahim, F (Author), Taha, M (Author), Ullah, H (Author), Zaman, K (Author)
Format: Article
Language:English
Published: 2019
Subjects:
ACETYLCHOLINESTERASE
alpha-glucosidase
ANALOGS
BETA-GLUCURONIDASE
BIOLOGICAL EVALUATION
DERIVATIVES
IN-VITRO EVALUATION
molecular docking study
POTENTIAL INHIBITORS
QSAR
RHINOVIRUS
SAR
synthesis
thiosemicarbazide
THIOSEMICARBAZIDES
triazinoindole
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