Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expression in Dendritic Cells Using a Novel 3D Coculture System

Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expression in Dendritic Cells Using a Novel 3D Coculture System

The use of animal models in chemical safety testing will be significantly limited due to the recent introduction of the 3Rs principle of animal experimentation in research. Although several in vitro assays to predict the sensitizing potential of chemicals have been developed, these methods cannot di...

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Bibliographic Details
Main Authors: Izuru Mizoguchi, Mio Ohashi, Yukino Chiba, Hideaki Hasegawa, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
animal testing alternatives
3D coculture
respiratory sensitizers
skin sensitizers
dendritic cells
OX40L
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00929/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00929/full

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