Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin

Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin

Abstract Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal vaccines. Here we generated reassortant influenza virus rgH3N2 4xM2e virus (HA and NA f...

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Bibliographic Details
Main Authors: Bo Ryoung Park, Ki-Hye Kim, Tatiana Kotomina, Min-Chul Kim, Young-Man Kwon, Subbiah Jeeva, Yu-Jin Jung, Noopur Bhatnagar, Irina Isakova-Sivak, Daria Mezhenskaya, Larisa Rudenko, Bao-Zhong Wang, Sang-Moo Kang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83704-0

Internet

https://doi.org/10.1038/s41598-021-83704-0

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