M2e-based universal influenza vaccines: a historical overview and new approaches to development

by Daria Mezhenskaya, Irina Isakova-Sivak, Larisa Rudenko
Published 2019-10-01

A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats

by Daria Mezhenskaya, Irina Isakova-Sivak, Tatiana Kotomina, Victoria Matyushenko, Min-Chul Kim, Noopur Bhatnagar, Ki-Hye Kim, Sang-Moo Kang, Larisa Rudenko
Published 2021-02-01

Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge

by Daria Mezhenskaya, Irina Isakova-Sivak, Victoria Matyushenko, Svetlana Donina, Andrey Rekstin, Konstantin Sivak, Kirill Yakovlev, Anastasia Katelnikova, Kirill Kryshen, Valery Makarov, Larisa Rudenko
Published 2021-06-01

Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T-cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T-Cell Responses and Protect Mice against...

by Irina Isakova-Sivak, Victoria Matyushenko, Ekaterina Stepanova, Anastasia Matushkina, Tatiana Kotomina, Daria Mezhenskaya, Polina Prokopenko, Igor Kudryavtsev, Pavel Kopeykin, Konstantin Sivak, Larisa Rudenko
Published 2020-04-01

Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes

by Tatiana Kotomina, Irina Isakova-Sivak, Ki-Hye Kim, Bo Ryoung Park, Yu-Jin Jung, Youri Lee, Daria Mezhenskaya, Victoria Matyushenko, Sang-Moo Kang, Larisa Rudenko
Published 2020-11-01

Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

by Irina Isakova-Sivak, Victoria Matyushenko, Tatiana Kotomina, Irina Kiseleva, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Natalia Larionova, Daria Mezhenskaya, Konstantin Sivak, Arman Muzhikyan, Anastasia Katelnikova, Larisa Rudenko
Published 2019-07-01

Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens

by Anna Kirsteina, Inara Akopjana, Janis Bogans, Ilva Lieknina, Juris Jansons, Dace Skrastina, Tatjana Kazaka, Kaspars Tars, Irina Isakova-Sivak, Daria Mezhenskaya, Tatiana Kotomina, Victoria Matyushenko, Larisa Rudenko, Andris Kazaks
Published 2020-04-01

Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin

by Bo Ryoung Park, Ki-Hye Kim, Tatiana Kotomina, Min-Chul Kim, Young-Man Kwon, Subbiah Jeeva, Yu-Jin Jung, Noopur Bhatnagar, Irina Isakova-Sivak, Daria Mezhenskaya, Larisa Rudenko, Bao-Zhong Wang, Sang-Moo Kang
Published 2021-02-01