Bioactive Fluorenes. Part II. Unprecedented biologically active thiazole derivatives based-2,7-dichlorofluorene as competent DHFR inhibitors: Design, synthesis, and molecular docking approaches

Bioactive Fluorenes. Part II. Unprecedented biologically active thiazole derivatives based-2,7-dichlorofluorene as competent DHFR inhibitors: Design, synthesis, and molecular docking approaches

In this study, a new series of (4-(2,7-dichloro-9H-fluoren-4-yl)thiazol-yl)acetamide derivatives was synthesized, and the new heterocycles were completely characterized, evaluated for their antimicrobial activity, and screened for cytotoxic activity against human lung carcinoma (A-549) and human bre...

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Bibliographic Details
Main Authors: Reem I. Alsantali, Essam M. Hussein, Rami J. Obaid, Moataz Morad, Hatem M. Altass, Ahmed Alharbi, Ahmed M. Hameed, Rabab.S. Jassas, Mohamed A.S. Abourehab, Basim H. Asghar, Ziad Moussa, Saleh A. Ahmed
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Arabian Journal of Chemistry
Subjects:
Fluorene
Thiazole
Antimicrobial
Anti-cancer
Molecular docking
DHFR inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S187853522030099X

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http://www.sciencedirect.com/science/article/pii/S187853522030099X

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