Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells is a critical process in the immunopathology of infla...

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Bibliographic Details
Main Authors: Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767590?pdf=render

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http://europepmc.org/articles/PMC3767590?pdf=render

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