Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

by Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl
Published 2013-01-01

Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells

by Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Häfliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Bäbler, Kirstin Atrott, Silvia Lang, Michael Scharl
Published 2021-01-01

Large-Scale Integrative Analysis of Epigenetic Modifications Induced by Isotretinoin, Doxycycline and Metronidazole in Murine Colonic Intestinal Epithelial Cells

by Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Felix Rost, Irina Leonardi, Claudia Stanzel, Tina Raselli, Stephanie Kasper, Pedro A. Ruiz, Gerhard Rogler
Published 2017-12-01

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N₂ in Dendritic Cells to Protect from Elevated Colitis

by Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Published 2021-06-01

A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis

by Cheryl de Vallière, Katharina Bäbler, Philipp Busenhart, Marlene Schwarzfischer, Chiaki Maeyashiki, Cordelia Schuler, Kirstin Atrott, Silvia Lang, Marianne R. Spalinger, Michael Scharl, Pedro A. Ruiz-Castro, Martin Hausmann, Gerhard Rogler
Published 2021-07-01

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

by Jesus Cosin-Roger, Marianne R Spalinger, Pedro A Ruiz, Claudia Stanzel, Anne Terhalle, Lutz Wolfram, Hassan Melhem, Kirstin Atrott, Silvia Lang, Isabelle Frey-Wagner, Michael Fried, Michael Scharl, Martin Hausmann, Gerhard Rogler
Published 2018-01-01

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

by Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Philipp Busenhart, Claudia Gottier, Dunja Mrdjen, Juliana Komuczki, Marcin Wawrzyniak, Silvia Lang, Kirstin Atrott, Burkhard Becher, Gerhard Rogler, Gerhard Rogler, Michael Scharl, Michael Scharl, Marianne R. Spalinger
Published 2020-08-01

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

by Marianne R. Spalinger, Roberto Manzini, Larissa Hering, Julianne B. Riggs, Claudia Gottier, Silvia Lang, Kirstin Atrott, Antonia Fettelschoss, Florian Olomski, Thomas M. Kündig, Michael Fried, Declan F. McCole, Gerhard Rogler, Michael Scharl
Published 2018-02-01

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

by Jesus Cosin-Roger, Simona Simmen, Hassan Melhem, Kirstin Atrott, Isabelle Frey-Wagner, Martin Hausmann, Cheryl de Vallière, Marianne R. Spalinger, Patrick Spielmann, Roland H. Wenger, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Pedro A. Ruiz
Published 2017-07-01

Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa

by Simona Simmen, Max Maane, Sarah Rogler, Katherina Baebler, Silvia Lang, Jesus Cosin-Roger, Kirstin Atrott, Isabelle Frey-Wagner, Partick Spielmann, Roland H. Wenger, Bruce Weder, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Cheryl de Vallière, Martin Hausmann, Pedro A. Ruiz
Published 2021-03-01

Hypoxia Positively Regulates the Expression of pH-Sensing G-ProteinâCoupled Receptor OGR1 (GPR68)Summary

by Cheryl de Vallière, Jesus Cosin-Roger, Simona Simmen, Kirstin Atrott, Hassan Melhem, Jonas Zeitz, Mehdi Madanchi, Irina Tcymbarevich, Michael Fried, Gerd A. Kullak-Ublick, Stephan R. Vavricka, Benjamin Misselwitz, Klaus Seuwen, Carsten A. Wagner, Jyrki J. Eloranta, Gerhard Rogler, Pedro A. Ruiz
Published 2016-11-01

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis[S]

by Tina Raselli, Tom Hearn, Annika Wyss, Kirstin Atrott, Alain Peter, Isabelle Frey-Wagner, Marianne R. Spalinger, Ewerton M. Maggio, Andreas W. Sailer, Johannes Schmitt, Philipp Schreiner, Anja Moncsek, Joachim Mertens, Michael Scharl, William J. Griffiths, Marco Bueter, Andreas Geier, Gerhard Rogler, Yuqin Wang, Benjamin Misselwitz
Published 2019-07-01