Bioconductor workflow for single-cell RNA sequencing: Normalization, dimensionality reduction, clustering, and lineage inference [version 1; referees: 1 approved, 2 approved with reservations]

Novel single-cell transcriptome sequencing assays allow researchers to measure gene expression levels at the resolution of single cells and offer the unprecendented opportunity to investigate at the molecular level fundamental biological questions, such as stem cell differentiation or the discovery...

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Bibliographic Details
Main Authors: Fanny Perraudeau, Davide Risso, Kelly Street, Elizabeth Purdom, Sandrine Dudoit
Format: Article
Language:English
Published: F1000 Research Ltd 2017-07-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/6-1158/v1