Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

Abstract Mammalian ecto-ADP-ribosyltransferases (ecto-ARTs or also ARTCs) catalyze the ADP-ribosylation of cell surface proteins using extracellular nicotinamide adenine dinucleotide (NAD+) as substrate. By this post-translational protein modification, ecto-ARTs modulate the function of various targ...

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Main Authors: Björn Rissiek, Stephan Menzel, Mario Leutert, Maike Cordes, Sarah Behr, Larissa Jank, Peter Ludewig, Mathias Gelderblom, Anne Rissiek, Sahil Adriouch, Friedrich Haag, Michael O. Hottiger, Friedrich Koch-Nolte, Tim Magnus
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-16613-w

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https://doi.org/10.1038/s41598-017-16613-w

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