Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells

Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells

Regulatory T cells are integral to the regulation of autoimmune and anti-tumor immune responses. However, several studies have suggested that changes in T cell signaling networks can result in T cells that are resistant to the suppressive effects of regulatory T cells. Here, we investigated the role...

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Bibliographic Details
Main Authors: SeongJun Han, Douglas C. Chung, Michael St. Paul, Zhe Qi Liu, Carlos Garcia-Batres, Alisha R. Elford, Charles W. Tran, Laurence Chapatte, Pamela S. Ohashi
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
immune regulation
t cell
treg
cytokine
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1737368

Internet

http://dx.doi.org/10.1080/2162402X.2020.1737368

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