Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn's disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs)....

Full description

Bibliographic Details
Main Authors: Jesus Cosin-Roger, Marianne R Spalinger, Pedro A Ruiz, Claudia Stanzel, Anne Terhalle, Lutz Wolfram, Hassan Melhem, Kirstin Atrott, Silvia Lang, Isabelle Frey-Wagner, Michael Fried, Michael Scharl, Martin Hausmann, Gerhard Rogler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5814018?pdf=render

Internet

http://europepmc.org/articles/PMC5814018?pdf=render

Similar Items