Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging. The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10-100 fold lower than other glycoproteins of pharmaceutical interest. Moreover, Envs produced in CHO cells are typically...

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Bibliographic Details
Main Authors: Sara M O'Rourke, Gabriel Byrne, Gwen Tatsuno, Meredith Wright, Bin Yu, Kathryn A Mesa, Rachel C Doran, David Alexander, Phillip W Berman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6071959?pdf=render

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http://europepmc.org/articles/PMC6071959?pdf=render

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